Unusual autoimmune nonhematologic complications in chronic lymphocytic leukemia

Moonjung Jung, Lawrence Rice

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Autoimmune phenomena are well known to complicate chronic lymphocytic leukemia (CLL) and occur in 10% to 25% of patients. Hematologic autoimmune complications, particularly autoimmune hemolytic anemia and immune thrombocytopenia, are much more common than nonhematologic complications. We present 6 cases of patients who exhibited uncommon complications of CLL: myasthenia gravis, acquired von Willebrand disease, bullous pemphigoid, and acquired angioedema. In our patients, the activity and recrudescences of these complications were highly associated with CLL remission or progression. More awareness of the association of CLL with these complications could facilitate earlier diagnosis and effective treatment.

Original languageEnglish (US)
Pages (from-to)S10-S13
JournalClinical Lymphoma, Myeloma and Leukemia
Issue numberSUPPL.1
StatePublished - Jun 2011


  • Acquired angioedema
  • Autoimmune disorder
  • Bullous pemphigoid
  • Chronic lymphocytic leukemia
  • Myasthenia gravis
  • von Willebrand disease

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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