Unraveling the signal-transduction networks in cancer metastasis [life sciences]

Guangxu Jin, Kemi Cui, Xiaobo Zhou, Stephen T.C. Wong

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Metastasis is a major cause of morbidity and mortality in cancer patients. For example, in the United States, the five-year relative survival in local prostate cancer patients is nearly 100% while it is only 32% in patients with distant metastases (http://www.cancer.org). Similar to many types of malignant tumors, prostate cancer develops from the mutations or disregulation of various genes involved in regulation signal transduction and the cell cycle [1]. The discovery of molecular pathways that significantly contribute to tumor metastasis would provide specific targets and optimal strategies in prevention and treatment of such malignant diseases.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalIEEE Signal Processing Magazine
Issue number5
StatePublished - 2009


  • Bioinformatics
  • Cancer
  • Genomics
  • Network topology
  • Protein engineering
  • Proteins

ASJC Scopus subject areas

  • Signal Processing
  • Electrical and Electronic Engineering
  • Applied Mathematics


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