Unraveling the signal-transduction networks in cancer metastasis [life sciences]

Guangxu Jin; Kemi Cui; Xiaobo Zhou; Stephen T.C. Wong

doi:10.1109/MSP.2009.933384

Unraveling the signal-transduction networks in cancer metastasis [life sciences]

Guangxu Jin, Kemi Cui, Xiaobo Zhou, Stephen T.C. Wong

Academic Institute

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Metastasis is a major cause of morbidity and mortality in cancer patients. For example, in the United States, the five-year relative survival in local prostate cancer patients is nearly 100% while it is only 32% in patients with distant metastases (http://www.cancer.org). Similar to many types of malignant tumors, prostate cancer develops from the mutations or disregulation of various genes involved in regulation signal transduction and the cell cycle [1]. The discovery of molecular pathways that significantly contribute to tumor metastasis would provide specific targets and optimal strategies in prevention and treatment of such malignant diseases.

Original language	English (US)
Pages (from-to)	129-132
Number of pages	4
Journal	IEEE Signal Processing Magazine
Volume	26
Issue number	5
DOIs	https://doi.org/10.1109/MSP.2009.933384
State	Published - 2009

Keywords

Bioinformatics
Cancer
Genomics
Network topology
Protein engineering
Proteins

ASJC Scopus subject areas

Signal Processing
Electrical and Electronic Engineering
Applied Mathematics

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10.1109/MSP.2009.933384

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title = "Unraveling the signal-transduction networks in cancer metastasis [life sciences]",

abstract = "Metastasis is a major cause of morbidity and mortality in cancer patients. For example, in the United States, the five-year relative survival in local prostate cancer patients is nearly 100% while it is only 32% in patients with distant metastases (http://www.cancer.org). Similar to many types of malignant tumors, prostate cancer develops from the mutations or disregulation of various genes involved in regulation signal transduction and the cell cycle [1]. The discovery of molecular pathways that significantly contribute to tumor metastasis would provide specific targets and optimal strategies in prevention and treatment of such malignant diseases.",

keywords = "Bioinformatics, Cancer, Genomics, Network topology, Protein engineering, Proteins",

author = "Guangxu Jin and Kemi Cui and Xiaobo Zhou and Wong, {Stephen T.C.}",

note = "Funding Information: This research is funded by NIH R01LM08696, R01LM009161, and R01AG028928.",

year = "2009",

doi = "10.1109/MSP.2009.933384",

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pages = "129--132",

journal = "IEEE Signal Processing Magazine",

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TY - JOUR

T1 - Unraveling the signal-transduction networks in cancer metastasis [life sciences]

AU - Jin, Guangxu

AU - Cui, Kemi

AU - Zhou, Xiaobo

AU - Wong, Stephen T.C.

N1 - Funding Information: This research is funded by NIH R01LM08696, R01LM009161, and R01AG028928.

PY - 2009

Y1 - 2009

N2 - Metastasis is a major cause of morbidity and mortality in cancer patients. For example, in the United States, the five-year relative survival in local prostate cancer patients is nearly 100% while it is only 32% in patients with distant metastases (http://www.cancer.org). Similar to many types of malignant tumors, prostate cancer develops from the mutations or disregulation of various genes involved in regulation signal transduction and the cell cycle [1]. The discovery of molecular pathways that significantly contribute to tumor metastasis would provide specific targets and optimal strategies in prevention and treatment of such malignant diseases.

AB - Metastasis is a major cause of morbidity and mortality in cancer patients. For example, in the United States, the five-year relative survival in local prostate cancer patients is nearly 100% while it is only 32% in patients with distant metastases (http://www.cancer.org). Similar to many types of malignant tumors, prostate cancer develops from the mutations or disregulation of various genes involved in regulation signal transduction and the cell cycle [1]. The discovery of molecular pathways that significantly contribute to tumor metastasis would provide specific targets and optimal strategies in prevention and treatment of such malignant diseases.

KW - Bioinformatics

KW - Cancer

KW - Genomics

KW - Network topology

KW - Protein engineering

KW - Proteins

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DO - 10.1109/MSP.2009.933384

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JO - IEEE Signal Processing Magazine

JF - IEEE Signal Processing Magazine

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Unraveling the signal-transduction networks in cancer metastasis [life sciences]

Abstract

Keywords

ASJC Scopus subject areas

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