Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism

Wendi Zhang; Chi Wang; Zhongjun Li; Zhenzhen Lu; Yiye Li; Jun Jie Yin; Yu Ting Zhou; Xingfa Gao; Ying Fang; Guangjun Nie; Yuliang Zhao

doi:10.1002/adma.201202678

Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism

Wendi Zhang, Chi Wang, Zhongjun Li, Zhenzhen Lu, Yiye Li, Jun Jie Yin, Yu Ting Zhou, Xingfa Gao, Ying Fang, Guangjun Nie, Yuliang Zhao

Houston Methodist

Research output: Contribution to journal › Article › peer-review

228 Scopus citations

Abstract

Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.

Original language	English (US)
Pages (from-to)	5391-5397
Number of pages	7
Journal	Advanced Materials
Volume	24
Issue number	39
DOIs	https://doi.org/10.1002/adma.201202678
State	Published - Oct 9 2012

Keywords

electron transfer
functional materials
graphene oxide
nanotoxicity

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201202678

Cite this

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title = "Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism",

abstract = "Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.",

keywords = "electron transfer, functional materials, graphene oxide, nanotoxicity",

author = "Wendi Zhang and Chi Wang and Zhongjun Li and Zhenzhen Lu and Yiye Li and Yin, \{Jun Jie\} and Zhou, \{Yu Ting\} and Xingfa Gao and Ying Fang and Guangjun Nie and Yuliang Zhao",

year = "2012",

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journal = "Advanced Materials",

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T1 - Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism

AU - Zhang, Wendi

AU - Wang, Chi

AU - Li, Zhongjun

AU - Lu, Zhenzhen

AU - Li, Yiye

AU - Yin, Jun Jie

AU - Zhou, Yu Ting

AU - Gao, Xingfa

AU - Fang, Ying

AU - Nie, Guangjun

AU - Zhao, Yuliang

PY - 2012/10/9

Y1 - 2012/10/9

N2 - Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.

AB - Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.

KW - electron transfer

KW - functional materials

KW - graphene oxide

KW - nanotoxicity

UR - https://www.scopus.com/pages/publications/84866990822

UR - https://www.scopus.com/inward/citedby.url?scp=84866990822&partnerID=8YFLogxK

U2 - 10.1002/adma.201202678

DO - 10.1002/adma.201202678

M3 - Article

C2 - 22927326

AN - SCOPUS:84866990822

SN - 0935-9648

VL - 24

SP - 5391

EP - 5397

JO - Advanced Materials

JF - Advanced Materials

IS - 39

ER -

Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism

Abstract

Keywords

ASJC Scopus subject areas

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