Unraveling multilayered extracellular vesicles: Speculation on cause

Kelly Broad, Sierra A. Walker, Irina Davidovich, Kenneth Witwer, Yeshayahu Talmon, Joy Wolfram

Research output: Contribution to journalLetterpeer-review

18 Scopus citations


Extracellular vesicles (EVs) are cell-released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.

Original languageEnglish (US)
Article numbere12309
Pages (from-to)e12309
JournalJournal of Extracellular Vesicles
Issue number2
StatePublished - Feb 2023


  • ectosome
  • exosome
  • microvesicle
  • multilamellar
  • unilamellar
  • Biological Transport
  • Cell Communication
  • Extracellular Vesicles/metabolism

ASJC Scopus subject areas

  • Cell Biology
  • Histology


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