Unp, a mouse gene related to the tre oncogene

K. Gupta, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, D. A. Gray

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


We have cloned cDNAs from a novel gene designated Unp. Unp cDNAs contain a large open reading frame that would encode a protein of 89 kDa. The predicted protein contains a putative nuclear localization signal, as well as consensus sequences for binding to the retinoblas-toma gene product. The latter elements are contained within a region having strong similarity to the human tre oncogene. We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies.

Original languageEnglish (US)
Pages (from-to)2307-2310
Number of pages4
Issue number8
StatePublished - 1993

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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