Unp, a mouse gene related to the tre oncogene

K. Gupta; N. G. Copeland; D. J. Gilbert; N. A. Jenkins; D. A. Gray

Unp, a mouse gene related to the tre oncogene

K. Gupta, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, D. A. Gray

Research output: Contribution to journal › Article › peer-review

Abstract

We have cloned cDNAs from a novel gene designated Unp. Unp cDNAs contain a large open reading frame that would encode a protein of 89 kDa. The predicted protein contains a putative nuclear localization signal, as well as consensus sequences for binding to the retinoblas-toma gene product. The latter elements are contained within a region having strong similarity to the human tre oncogene. We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies.

Original language	English (US)
Pages (from-to)	2307-2310
Number of pages	4
Journal	Oncogene
Volume	8
Issue number	8
State	Published - 1993

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

Cite this

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year = "1993",

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AU - Gupta, K.

AU - Copeland, N. G.

AU - Gilbert, D. J.

AU - Jenkins, N. A.

AU - Gray, D. A.

PY - 1993

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N2 - We have cloned cDNAs from a novel gene designated Unp. Unp cDNAs contain a large open reading frame that would encode a protein of 89 kDa. The predicted protein contains a putative nuclear localization signal, as well as consensus sequences for binding to the retinoblas-toma gene product. The latter elements are contained within a region having strong similarity to the human tre oncogene. We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies.

AB - We have cloned cDNAs from a novel gene designated Unp. Unp cDNAs contain a large open reading frame that would encode a protein of 89 kDa. The predicted protein contains a putative nuclear localization signal, as well as consensus sequences for binding to the retinoblas-toma gene product. The latter elements are contained within a region having strong similarity to the human tre oncogene. We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies.

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JO - Oncogene

JF - Oncogene

IS - 8

ER -

Unp, a mouse gene related to the tre oncogene

Abstract

ASJC Scopus subject areas

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