TY - JOUR
T1 - Unleashing the potential of cell biomimetic nanoparticles
T2 - Strategies and challenges in their design and fabrication for therapeutic applications
AU - Zinger, Assaf
N1 - Funding Information:
AZ acknowledges support and awards from the Israel Science Foundation award (164/22, 165/22), the Israel Cancer Research Foundation award (21-206-RCDA), the Israel Cancer Association award (20230006), the Russell Berrie Nanotechnology Institute (NEVET 122317), Alon Fellowship and Noam Seidan Fellowship in Nanotechnology and Optoelectronics. AZ acknowledges Dr. Nitzan Krinsky, Dr. Omer Adir, and Dr. Zvi Yaari's for their ideas in preparing this manuscript and highly appreciates the feedback provided by external experts while finalizing the manuscript. Figs. 1 & 2 were created using Biorender.com .
Publisher Copyright:
© 2023
PY - 2023/6
Y1 - 2023/6
N2 - In this contribution to the Orations - New Horizons of the Journal of Controlled Release, I present design strategies for the two main biomimetic nanoparticles (BNP) groups: BNP composed of isolated cell membrane proteins, and BNP composed of the native cell membrane. I furthermore describe BNP fabrication methods and analyze their advantages and challenges. Finally, I suggest future therapeutic applications of each BNP group and propose a new revolutionary concept for their use.
AB - In this contribution to the Orations - New Horizons of the Journal of Controlled Release, I present design strategies for the two main biomimetic nanoparticles (BNP) groups: BNP composed of isolated cell membrane proteins, and BNP composed of the native cell membrane. I furthermore describe BNP fabrication methods and analyze their advantages and challenges. Finally, I suggest future therapeutic applications of each BNP group and propose a new revolutionary concept for their use.
KW - Biomimetic nanoparticles
KW - Cell membrane
KW - Drug delivery
KW - Nanomedicine
KW - Translational therapeutics
KW - Nanoparticles
KW - Membrane Proteins/metabolism
KW - Biomimetics/methods
KW - Cell Membrane/metabolism
KW - Biomimetic Materials
KW - Drug Delivery Systems/methods
UR - http://www.scopus.com/inward/record.url?scp=85160012217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85160012217&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2023.04.040
DO - 10.1016/j.jconrel.2023.04.040
M3 - Article
C2 - 37146767
AN - SCOPUS:85160012217
VL - 358
SP - 591
EP - 600
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
ER -