TY - JOUR
T1 - Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscale
AU - Bruno, Giacomo
AU - Di Trani, Nicola
AU - Hood, R. Lyle
AU - Zabre, Erika
AU - Filgueira, Carly Sue
AU - Canavese, Giancarlo
AU - Jain, Priya
AU - Smith, Zachary
AU - Demarchi, Danilo
AU - Hosali, Sharath
AU - Pimpinelli, Alberto
AU - Ferrari, Mauro
AU - Grattoni, Alessandro
N1 - Funding Information:
We also acknowledge financial support from the Center for the Advancement of Science in Space (CASIS) GA-2013-118, CASIS GA- 2014-145, funding from the Houston Methodist Research Institute, NIH R21 GM 111544, NanoMedical Systems, and the Nancy Owens Memorial Foundation. Membranes were provided by NanoMedical Systems
Funding Information:
We thank Dr. Alma Zecevic and Dr. Lidong Qin for helpful discussions and Randy Goodall and Lee Hudson for their support. We also acknowledge financial support from the Center for the Advancement of Science in Space (CASIS) GA-2013-118, CASIS GA-2014-145, funding from the Houston Methodist Research Institute, NIH R21 GM 111544, NanoMedical Systems, and the Nancy Owens Memorial Foundation. Membranes were provided by NanoMedical Systems.
Publisher Copyright:
© 2018 The Author(s).
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/4/27
Y1 - 2018/4/27
N2 - Ionic transport through nanofluidic systems is a problem of fundamental interest in transport physics and has broad relevance in desalination, fuel cells, batteries, filtration, and drug delivery. When the dimension of the fluidic system approaches the size of molecules in solution, fluid properties are not homogeneous and a departure in behavior is observed with respect to continuum-based theories. Here we present a systematic study of the transport of charged and neutral small molecules in an ideal nanofluidic platform with precise channels from the sub-microscale to the ultra-nanoscale (<5 nm). Surprisingly, we find that diffusive transport of nano-confined neutral molecules matches that of charged molecules, as though the former carry an effective charge. Further, approaching the ultra-nanoscale molecular diffusivities suddenly drop by up to an order of magnitude for all molecules, irrespective of their electric charge. New theoretical investigations will be required to shed light onto these intriguing results.
AB - Ionic transport through nanofluidic systems is a problem of fundamental interest in transport physics and has broad relevance in desalination, fuel cells, batteries, filtration, and drug delivery. When the dimension of the fluidic system approaches the size of molecules in solution, fluid properties are not homogeneous and a departure in behavior is observed with respect to continuum-based theories. Here we present a systematic study of the transport of charged and neutral small molecules in an ideal nanofluidic platform with precise channels from the sub-microscale to the ultra-nanoscale (<5 nm). Surprisingly, we find that diffusive transport of nano-confined neutral molecules matches that of charged molecules, as though the former carry an effective charge. Further, approaching the ultra-nanoscale molecular diffusivities suddenly drop by up to an order of magnitude for all molecules, irrespective of their electric charge. New theoretical investigations will be required to shed light onto these intriguing results.
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U2 - 10.1038/s41467-018-04133-8
DO - 10.1038/s41467-018-04133-8
M3 - Article
C2 - 29703954
AN - SCOPUS:85046245886
VL - 9
JO - Nat Commun
JF - Nat Commun
SN - 2041-1723
IS - 1
M1 - 1682
ER -