Ultrastructural observations on smooth muscle tumors

Bruce Mackay, Jae Ro, Craig Floyd, Nelson G. Ordóñez

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The ultrastructure of a series of primary and metastatic smooth muscle tumors is reviewed. Myofilaments and other smooth muscle features were present in all primary leiomyosarcomas of the soft tissues and uterus. They were also present but were less plentiful in most of the metastatic leiomyosarcomas. Electron microscopy is therefore a useful method to establish the diagnosis of a suspected leiomyosarcoma. Stromal tumors of the gastro-intestinal tract may require correlated immunocytochemical and ultrastructural studies for their identification: 9 of the 50 cases examined were positive with immunostaining for S-100 protein, and 16 tumors with epithelioid transformation did not show evidence of smooth muscle differentiation by electron microscopy.

Original languageEnglish (US)
Pages (from-to)593-607
Number of pages15
JournalUltrastructural Pathology
Issue number5-6
StatePublished - 1987


  • Hemangiopericytoma
  • Leiomyosarcoma
  • Myofibroblast
  • Myofilaments

ASJC Scopus subject areas

  • Structural Biology
  • Pathology and Forensic Medicine


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