Ultrastructural localization of aluminium in liver of aluminium maltol‐treated rabbits by laser microprobe mass analysis

D. Vandeputte, R. E. Van Grieken, W. A. Jacob, J. Savory, R. L. Bertholf, M. R. Wills

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

By means of laser microprobe mass analysis (LAMMA), we have studied the ultrastructural localization of aluminium in livers of aluminium maltol‐treated rabbits. This animal model was developed to study long‐term aluminium toxicity using systemic (intravenous) administration of aluminium. We could only detect aluminium in electron‐dense inclusion bodies found in large, sometimes multinucleated cells. These results prove that the actual observation of aluminium deposits in liver with LAMMA gives more information than bulk analysis and can be very useful to explore mechanisms of toxicity.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalBiomedical & environmental mass spectrometry
Volume18
Issue number8
DOIs
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pollution

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