Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T2-Weighted Magnetic Resonance Imaging

Yaling Wang, Chao Xu, Yanan Chang, Lina Zhao, Kai Zhang, Yuliang Zhao, Fuping Gao, Xueyun Gao

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


A facile method to synthesize ultrasmall-sized supermagnetic iron oxide nanoparticles with good monodispersity and high relaxivity is desired for magnetic resonance imaging (MRI) technology. Herein, we have developed a one-step method to direct the formation of superparamagnetic iron oxide nanoparticle (uBSPIO) using albumin under mild conditions. The resulting uBSPIO possess ultrasmall size (4.78 ± 0.55 nm) and super high MR relaxivity (444.56 ± 8.82 mM-1 s-1). After grafted by the luteinizing hormone release hormone peptide (LHRH), the uBSPIO could targeted and accumulated in the tumor site. Finally, the uBSPIOs had good stability and did not induce cytotoxicity in vitro or major organ toxicity in vivo. The uBSPIOs are promising contrast agents for MRI.

Original languageEnglish (US)
Pages (from-to)28959-28966
Number of pages8
JournalACS Applied Materials and Interfaces
Issue number34
StatePublished - Aug 30 2017


  • BSA
  • T-weighted magnetic resonance imaging
  • biomineralization
  • ultrasmall superparamagnetic iron oxide

ASJC Scopus subject areas

  • Materials Science(all)


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