Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics

Ming Li; Ji Qi; Jianbo Zeng; Fusheng Zhao; Ulrich Strych; Richard C. Willson; Wei Chuan Shih

Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics

Ming Li, Ji Qi, Jianbo Zeng, Fusheng Zhao, Ulrich Strych, Richard C. Willson, Wei Chuan Shih

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report a novel microfluidic sensing platform enabled by disk-shaped nanoporous gold nanoparticles (NPGNs), representing a unique class of hierarchical plasmonic nanoparticle. NPGNs possess large specific surface area and high-density, internal plasmonic "hot-spots" with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of disk-shaped NPGNs can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. By surface-enhanced Raman scattering, we demonstrate label-free sensing of biomolecules and in situ monitoring of individual DNA hybridization.

Original language	English (US)
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	1823-1825
Number of pages	3
ISBN (Print)	9780979806476
State	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: Oct 26 2014 → Oct 30 2014

Other

Other	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	10/26/14 → 10/30/14

Keywords

Label-free
Molecular sensing
Plasmonics
SERS

ASJC Scopus subject areas

Control and Systems Engineering

Cite this

Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics. / Li, Ming; Qi, Ji; Zeng, Jianbo et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 1823-1825.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Li, M, Qi, J, Zeng, J, Zhao, F, Strych, U, Willson, RC & Shih, WC 2014, Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, pp. 1823-1825, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 10/26/14.

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title = "Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics",

abstract = "We report a novel microfluidic sensing platform enabled by disk-shaped nanoporous gold nanoparticles (NPGNs), representing a unique class of hierarchical plasmonic nanoparticle. NPGNs possess large specific surface area and high-density, internal plasmonic {"}hot-spots{"} with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of disk-shaped NPGNs can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. By surface-enhanced Raman scattering, we demonstrate label-free sensing of biomolecules and in situ monitoring of individual DNA hybridization.",

keywords = "Label-free, Molecular sensing, Plasmonics, SERS",

author = "Ming Li and Ji Qi and Jianbo Zeng and Fusheng Zhao and Ulrich Strych and Willson, \{Richard C.\} and Shih, \{Wei Chuan\}",

year = "2014",

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isbn = "9780979806476",

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booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

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note = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

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T1 - Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics

AU - Li, Ming

AU - Qi, Ji

AU - Zeng, Jianbo

AU - Zhao, Fusheng

AU - Strych, Ulrich

AU - Willson, Richard C.

AU - Shih, Wei Chuan

PY - 2014

Y1 - 2014

N2 - We report a novel microfluidic sensing platform enabled by disk-shaped nanoporous gold nanoparticles (NPGNs), representing a unique class of hierarchical plasmonic nanoparticle. NPGNs possess large specific surface area and high-density, internal plasmonic "hot-spots" with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of disk-shaped NPGNs can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. By surface-enhanced Raman scattering, we demonstrate label-free sensing of biomolecules and in situ monitoring of individual DNA hybridization.

AB - We report a novel microfluidic sensing platform enabled by disk-shaped nanoporous gold nanoparticles (NPGNs), representing a unique class of hierarchical plasmonic nanoparticle. NPGNs possess large specific surface area and high-density, internal plasmonic "hot-spots" with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of disk-shaped NPGNs can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. By surface-enhanced Raman scattering, we demonstrate label-free sensing of biomolecules and in situ monitoring of individual DNA hybridization.

KW - Label-free

KW - Molecular sensing

KW - Plasmonics

KW - SERS

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M3 - Conference contribution

AN - SCOPUS:84941630091

SN - 9780979806476

SP - 1823

EP - 1825

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics

Abstract

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Keywords

ASJC Scopus subject areas

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