Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis

Cong Wang; Julia Yu Fong Chang; Chaofeng Yang; Yanqing Huang; Junchen Liu; Pan You; Wallace L. McKeehan; Fen Wang; Xiaokun Li

doi:10.1074/jbc.M113.463620

Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis

Cong Wang, Julia Yu Fong Chang, Chaofeng Yang, Yanqing Huang, Junchen Liu, Pan You, Wallace L. McKeehan, Fen Wang, Xiaokun Li

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Background: How Fgfr1 mutations cause cleft palate is unclear. Results: Deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. Conclusion: FGFR1 signaling in cranial neural crest (CNC) cells regulates palate shelf growth and fusion during palatogenesis. Significance: The finding for the first time demonstrates how FGF signaling in CNC cells regulates palatogenesis.

Original language	English (US)
Pages (from-to)	22174-22183
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.463620
State	Published - Jul 26 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.463620

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title = "Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis",

abstract = "Background: How Fgfr1 mutations cause cleft palate is unclear. Results: Deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. Conclusion: FGFR1 signaling in cranial neural crest (CNC) cells regulates palate shelf growth and fusion during palatogenesis. Significance: The finding for the first time demonstrates how FGF signaling in CNC cells regulates palatogenesis.",

author = "Cong Wang and Chang, \{Julia Yu Fong\} and Chaofeng Yang and Yanqing Huang and Junchen Liu and Pan You and McKeehan, \{Wallace L.\} and Fen Wang and Xiaokun Li",

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T1 - Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis

AU - Wang, Cong

AU - Chang, Julia Yu Fong

AU - Yang, Chaofeng

AU - Huang, Yanqing

AU - Liu, Junchen

AU - You, Pan

AU - McKeehan, Wallace L.

AU - Wang, Fen

AU - Li, Xiaokun

PY - 2013/7/26

Y1 - 2013/7/26

N2 - Background: How Fgfr1 mutations cause cleft palate is unclear. Results: Deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. Conclusion: FGFR1 signaling in cranial neural crest (CNC) cells regulates palate shelf growth and fusion during palatogenesis. Significance: The finding for the first time demonstrates how FGF signaling in CNC cells regulates palatogenesis.

AB - Background: How Fgfr1 mutations cause cleft palate is unclear. Results: Deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. Conclusion: FGFR1 signaling in cranial neural crest (CNC) cells regulates palate shelf growth and fusion during palatogenesis. Significance: The finding for the first time demonstrates how FGF signaling in CNC cells regulates palatogenesis.

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UR - https://www.scopus.com/inward/citedby.url?scp=84881222338&partnerID=8YFLogxK

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DO - 10.1074/jbc.M113.463620

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SP - 22174

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 30

ER -

Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis

Abstract

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