TY - JOUR
T1 - Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis
AU - Wang, Cong
AU - Chang, Julia Yu Fong
AU - Yang, Chaofeng
AU - Huang, Yanqing
AU - Liu, Junchen
AU - You, Pan
AU - McKeehan, Wallace L.
AU - Wang, Fen
AU - Li, Xiaokun
PY - 2013/7/26
Y1 - 2013/7/26
N2 - Background: How Fgfr1 mutations cause cleft palate is unclear. Results: Deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. Conclusion: FGFR1 signaling in cranial neural crest (CNC) cells regulates palate shelf growth and fusion during palatogenesis. Significance: The finding for the first time demonstrates how FGF signaling in CNC cells regulates palatogenesis.
AB - Background: How Fgfr1 mutations cause cleft palate is unclear. Results: Deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. Conclusion: FGFR1 signaling in cranial neural crest (CNC) cells regulates palate shelf growth and fusion during palatogenesis. Significance: The finding for the first time demonstrates how FGF signaling in CNC cells regulates palatogenesis.
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U2 - 10.1074/jbc.M113.463620
DO - 10.1074/jbc.M113.463620
M3 - Article
C2 - 23754280
AN - SCOPUS:84881222338
SN - 0021-9258
VL - 288
SP - 22174
EP - 22183
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 30
ER -