TY - JOUR
T1 - Tympanic membrane perforations in the diabetic rat
T2 - A model of impaired wound healing
AU - Vrabec, J. T.
N1 - Funding Information:
Supported in part by a grant from the University of Texas Medical Branch Small Grant Program (No. 93-10-066).
PY - 1998
Y1 - 1998
N2 - Animal models of type I and type II diabetes mellitus have been studied intensively in an effort to define the pathophysiology of the diabetic condition. An often-observed clinical manifestation of diabetes is poor wound repair. Thus diabetic animals have emerged as useful models for the study of impaired wound healing. The healing of acute tympanic membrane (TM) perforations in diabetic animals has not been reported. This investigation compares time to closure of a standardized TM perforation in rats with streplozotocin-induced diabetes, Zucker diabetic fatty rats, and normal control rats. The Zucker diabetic fatty rats demonstrate a significantly prolonged time to closure compared with the other two groups. This animal model may be useful for future study of TM wound repair.
AB - Animal models of type I and type II diabetes mellitus have been studied intensively in an effort to define the pathophysiology of the diabetic condition. An often-observed clinical manifestation of diabetes is poor wound repair. Thus diabetic animals have emerged as useful models for the study of impaired wound healing. The healing of acute tympanic membrane (TM) perforations in diabetic animals has not been reported. This investigation compares time to closure of a standardized TM perforation in rats with streplozotocin-induced diabetes, Zucker diabetic fatty rats, and normal control rats. The Zucker diabetic fatty rats demonstrate a significantly prolonged time to closure compared with the other two groups. This animal model may be useful for future study of TM wound repair.
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U2 - 10.1016/S0194-5998(98)70305-5
DO - 10.1016/S0194-5998(98)70305-5
M3 - Article
C2 - 9527107
AN - SCOPUS:0031900024
SN - 0194-5998
VL - 118
SP - 304
EP - 308
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 3 I
ER -