Tympanic membrane perforations in the diabetic rat: A model of impaired wound healing

J. T. Vrabec

doi:10.1016/S0194-5998(98)70305-5

Tympanic membrane perforations in the diabetic rat: A model of impaired wound healing

J. T. Vrabec

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Animal models of type I and type II diabetes mellitus have been studied intensively in an effort to define the pathophysiology of the diabetic condition. An often-observed clinical manifestation of diabetes is poor wound repair. Thus diabetic animals have emerged as useful models for the study of impaired wound healing. The healing of acute tympanic membrane (TM) perforations in diabetic animals has not been reported. This investigation compares time to closure of a standardized TM perforation in rats with streplozotocin-induced diabetes, Zucker diabetic fatty rats, and normal control rats. The Zucker diabetic fatty rats demonstrate a significantly prolonged time to closure compared with the other two groups. This animal model may be useful for future study of TM wound repair.

Original language	English (US)
Pages (from-to)	304-308
Number of pages	5
Journal	Otolaryngology - Head and Neck Surgery
Volume	118
Issue number	3 I
DOIs	https://doi.org/10.1016/S0194-5998(98)70305-5
State	Published - 1998

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1016/S0194-5998(98)70305-5

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title = "Tympanic membrane perforations in the diabetic rat: A model of impaired wound healing",

abstract = "Animal models of type I and type II diabetes mellitus have been studied intensively in an effort to define the pathophysiology of the diabetic condition. An often-observed clinical manifestation of diabetes is poor wound repair. Thus diabetic animals have emerged as useful models for the study of impaired wound healing. The healing of acute tympanic membrane (TM) perforations in diabetic animals has not been reported. This investigation compares time to closure of a standardized TM perforation in rats with streplozotocin-induced diabetes, Zucker diabetic fatty rats, and normal control rats. The Zucker diabetic fatty rats demonstrate a significantly prolonged time to closure compared with the other two groups. This animal model may be useful for future study of TM wound repair.",

author = "Vrabec, {J. T.}",

note = "Funding Information: Supported in part by a grant from the University of Texas Medical Branch Small Grant Program (No. 93-10-066). ",

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N1 - Funding Information: Supported in part by a grant from the University of Texas Medical Branch Small Grant Program (No. 93-10-066).

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AB - Animal models of type I and type II diabetes mellitus have been studied intensively in an effort to define the pathophysiology of the diabetic condition. An often-observed clinical manifestation of diabetes is poor wound repair. Thus diabetic animals have emerged as useful models for the study of impaired wound healing. The healing of acute tympanic membrane (TM) perforations in diabetic animals has not been reported. This investigation compares time to closure of a standardized TM perforation in rats with streplozotocin-induced diabetes, Zucker diabetic fatty rats, and normal control rats. The Zucker diabetic fatty rats demonstrate a significantly prolonged time to closure compared with the other two groups. This animal model may be useful for future study of TM wound repair.

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Tympanic membrane perforations in the diabetic rat: A model of impaired wound healing

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