Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma

Keyphrases

• Hepatocellular Carcinoma 100%
• Forward Genetics 100%
• Short Hairpin RNA (shRNA) 80%
• Cancer Genes 80%
• Hepatocellular Carcinoma Cells 60%
• SgRNA Library 60%
• Cell Proliferation 40%
• Cell Tumor 40%
• Mutagenesis 40%
• Ras Signaling 40%
• Xenograft Mice 40%
• Tumor Heterogeneity 40%
• Liver 20%
• Mouse Liver 20%
• Tumor 20%
• Transgenic Mice 20%
• Therapeutic Target 20%
• After Injection 20%
• Liver Cells 20%
• SiRNA Knockdown 20%
• Nude Mice 20%
• Tumor Growth 20%
• High-throughput Screening 20%
• Tumor Suppressor Gene 20%
• Small Molecule Inhibitors 20%
• Hepatitis B Surface Antigen (HBsAg) 20%
• Tumor Formation 20%
• Sleeping Beauty Transposon 20%
• Transposon 20%
• Whole Genome 20%
• Cells in Culture 20%
• Mutated Genes 20%
• Dual Inhibition 20%
• Guanosine 20%
• High-throughput Sequencing 20%
• Liver Cancer 20%
• Transposon mutagenesis 20%
• 2-step 20%
• Sorafenib 20%
• Multiple Persons 20%
• Protein Pathway 20%
• Library Screening 20%
• Hepatocellular Carcinoma Progression 20%
• Hepatocellular Adenoma 20%
• Formability 20%
• Human Hepatocellular Carcinoma Cell Line 20%
• Driver mutations 20%
• RalA 20%
• RalB 20%
• Passenger mutation 20%
• Number of Passengers 20%

Biochemistry, Genetics and Molecular Biology

• Oncogene 100%
• Genetic Screen 100%
• Forward Genetics 100%
• Small Hairpin RNA 100%
• Small Interfering RNA 100%
• Nude Mouse 75%
• Cell Proliferation 50%
• Mutagenesis 50%
• Transposable Element 50%
• Carcinogenesis 25%
• Mutated Genes 25%
• Transposon Mutagenesis 25%
• Tumor Progression 25%
• Transgenic Mouse 25%
• Tumor Suppressor Gene 25%
• Small Molecule 25%
• Guanosine 25%
• High Throughput Sequencing 25%
• Hepatitis B Virus 25%
• Sorafenib 25%
• RNA Knockdown 25%

Medicine and Dentistry

• Genetic Screen 100%
• Hepatocellular Carcinoma 100%
• Malignant Neoplasm 44%
• Short Hairpin RNA 44%
• Carcinoma Cell 33%
• Mutagenesis 33%
• Transposon 33%
• Cell Proliferation 22%
• Tumor Xenograft 22%
• Ras Signaling 22%
• Neoplasm 11%
• Tumor Progression 11%
• Carcinogenesis 11%
• Transgenic Mouse 11%
• Tumor Suppressor Gene 11%
• Membrane Antigen 11%
• Liver Cell 11%
• Guanosine 11%
• Liver Cancer 11%
• Hepatitis B Virus 11%
• Sorafenib 11%
• Hepatocellular Carcinoma Cell Line 11%
• Hepatocellular Adenoma 11%
• RNA Knockdown 11%