TY - JOUR
T1 - Two randomized, double-blind, placebo-controlled studies evaluating the S-Caine Peel for induction of local anesthesia before long-pulsed ND:YAG laser therapy for leg veins
AU - Chen, John Z.S.
AU - Alexiades-Armenakas, Macrene R.
AU - Bernstein, Leonard J.
AU - Jacobson, Laurie G.
AU - Friedman, Paul M.
AU - Geronemus, Roy G.
PY - 2003/10/1
Y1 - 2003/10/1
N2 - BACKGROUND. Topical anesthetics are valuable tools for many dermatologic procedures. OBJECTIVE. To evaluate the efficacy and safety of S-Caine Peel composed of 1:1 (wt:wt) mixture of 7% lidocaine and 7% tetracaine in the induction of local anesthesia before long-pulsed Nd:YAG laser therapy for leg veins. METHODS. Two randomized, double-blinded, placebo-controlled trials were performed. In study 1, 60 adults received S-Caine Peel and placebo cream for 30 or 60 minutes. Efficacy was evaluated by a patient visual analog scale and impression. The pain scale and impression were evaluated by the investigator and an independent observer. In study 2, 40 adults received 60- and 90-minute applications. RESULTS. In study 1, the 30- and 60-minute application times were grouped: Patients had adequate pain relief in 48% of S-Caine sites versus 23% of placebo sites (P<0.001). Investigators reported none-to-mild pain in 50% of active sites versus 33% of placebo sites (P = 0.007), with adequate anesthesia in 65% of active sites versus 43% of placebo sites (P = 0.002). The independent witness assessed none-to-mild pain in 52% of active sites versus 37% of placebo sites (P = 0.067). In study 2, investigators rated none-to-mild pain in 75% of 60-minute and 85% of 90-minute S-Caine sites versus 30% and 50% of placebo sites (P = 0.012 and P = 0.002, respectively), with adequate anesthesia in 70% and 85% of 60- and 90-minute of active sites versus 25% and 20% of placebo sites (P = 0.029 and P = 0.001, respectively). The independent witness rated none to mild pain in 80% and 85% of 60 and 90 minute of S-Caine sites versus 35% and 50% of placebo sites (P = 0.008 and P = 0.004). CONCLUSION. The S-Caine Peel provides safe and highly effective local anesthesia when applied for at least 60 minutes for laser therapy of leg veins. Facile removal of the peel provides a unique advantage and ease in administration.
AB - BACKGROUND. Topical anesthetics are valuable tools for many dermatologic procedures. OBJECTIVE. To evaluate the efficacy and safety of S-Caine Peel composed of 1:1 (wt:wt) mixture of 7% lidocaine and 7% tetracaine in the induction of local anesthesia before long-pulsed Nd:YAG laser therapy for leg veins. METHODS. Two randomized, double-blinded, placebo-controlled trials were performed. In study 1, 60 adults received S-Caine Peel and placebo cream for 30 or 60 minutes. Efficacy was evaluated by a patient visual analog scale and impression. The pain scale and impression were evaluated by the investigator and an independent observer. In study 2, 40 adults received 60- and 90-minute applications. RESULTS. In study 1, the 30- and 60-minute application times were grouped: Patients had adequate pain relief in 48% of S-Caine sites versus 23% of placebo sites (P<0.001). Investigators reported none-to-mild pain in 50% of active sites versus 33% of placebo sites (P = 0.007), with adequate anesthesia in 65% of active sites versus 43% of placebo sites (P = 0.002). The independent witness assessed none-to-mild pain in 52% of active sites versus 37% of placebo sites (P = 0.067). In study 2, investigators rated none-to-mild pain in 75% of 60-minute and 85% of 90-minute S-Caine sites versus 30% and 50% of placebo sites (P = 0.012 and P = 0.002, respectively), with adequate anesthesia in 70% and 85% of 60- and 90-minute of active sites versus 25% and 20% of placebo sites (P = 0.029 and P = 0.001, respectively). The independent witness rated none to mild pain in 80% and 85% of 60 and 90 minute of S-Caine sites versus 35% and 50% of placebo sites (P = 0.008 and P = 0.004). CONCLUSION. The S-Caine Peel provides safe and highly effective local anesthesia when applied for at least 60 minutes for laser therapy of leg veins. Facile removal of the peel provides a unique advantage and ease in administration.
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U2 - 10.1046/j.1524-4725.2003.29293.x
DO - 10.1046/j.1524-4725.2003.29293.x
M3 - Article
C2 - 12974697
AN - SCOPUS:0141507910
VL - 29
SP - 1012
EP - 1018
JO - Dermatologic Surgery
JF - Dermatologic Surgery
SN - 1076-0512
IS - 10
ER -