Two-dose steroid combined with two-dose daclizumab and tacrolimus regimen in liver transplant recipients

Wei qiang Ju, Xiao shun He, Ya li Tan, Lin wei Wu, Qiang Tai, An bin Hu, Dong ping Wang, Y. Ma, Xiao feng Zhu, Jie fu Huang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

OBJECTIVE: To investigate the efficiency and safety of two-dose steroid combined with two-dose daclizumab and tacrolimus (FK506) regimen in liver transplant recipients. METHODS: There were 74 patients who treated in the First Affiliated Hospital of Sun Yat-Sen University from September 2006 to March 2008. Expect for 7 patients who didn't measure up, 67 adult liver transplant recipients were randomized into two groups: conventional protocol group (n = 35) in which steroid was withdrawn in 3 months after operation, and two-dose steroid group (n = 32). Comparison of rejection, infection (bacteria, fungal and cytomegalovirus) and metabolic complications rates were studied between two groups. RESULTS: There were significant differences between two groups in the rate of early postoperation hyperglycemia, the average dosage of insulin consumption among hyperglycemia recipients as well as the rate of diabetes mellitus, hypertension and infection during the follow-up period (P < 0.05). The rate of hypertension in early postoperation period, hyperlipemia and rejection rate during the follow-up period were similar in two groups (P > 0.05). CONCLUSIONS: Two-dose steroid combined with two-dose daclizumab and tacrolimus would be a safe and efficient immunosuppression strategy without increase the acute rejection rate hazard, that could reduce post-transplant infection and other complications from side-effect of long-term usage of steroid.

Original languageEnglish (US)
Pages (from-to)1064-1066
Number of pages3
JournalZhonghua wai ke za zhi [Chinese journal of surgery]
Volume47
Issue number14
StatePublished - Jul 15 2009

ASJC Scopus subject areas

  • Medicine(all)

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