Abstract
We present multiscale computer simulations of the delivery of chemotherapy and the tumor cells' response to the therapy. Even in a best-case scenario of: constant drug release from the nanoparticles; one cell type, which is drug-sensitive and does not develop resistance; targeted nanoparticle delivery; and for model parameters calibrated to ensure sufficient drug or nanoparticle blood concentration to rapidly kill all cells in vitro; our analysis shows that convective and diffusive transport limitations in vivo are severe and that drug levels inside the tumor are far less than in vitro, leaving large parts of the tumor with inadequate drug concentration. The in vivo rate of tumor shrinkage is several orders of magnitude less than in vitro, and after some shrinkage the tumor may achieve a new mass equilibrium far above detectable levels. Adjuvant anti-angiogenic therapy "normalizing" the vasculature may ameliorate transport limitations, although leading to unwanted tumor fragmentation.
Original language | English (US) |
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Title of host publication | 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings |
Editors | M. Laudon, B. Romanowicz |
Pages | 120-123 |
Number of pages | 4 |
State | Published - Dec 1 2005 |
Event | 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States Duration: May 8 2005 → May 12 2005 |
Other
Other | 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 |
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Country/Territory | United States |
City | Anaheim, CA |
Period | 5/8/05 → 5/12/05 |
Keywords
- Chemotherapy
- Computer simulation
- Nanoparticles
- Tumor fragmentation
ASJC Scopus subject areas
- Engineering(all)