Twins lead to the prevention of atherosclerosis: Preliminary findings of international twin study 2009

Research output: Contribution to journalArticle

Adam Domonkos Tarnoki, David Laszlo Tarnoki, Maria Antonietta Stazi, Emanuela Medda, Rodolfo Cotichini, Pierleone Lucatelli, Emanuele Boatta, Chiara Zini, Claudio Baracchini, Giorgio Meneghetti, Lorenza Nisticó, Corrado Fagnani, Fabrizio Fanelli, Maria Fabrizia Giannoni, Marianna Gazzetti, Janos Osztovits, Gyorgy Jermendy, István Préda, Róbert Gábor Kiss, Levente Littvay & 9 others Julia Metneki, Tamas Horvath, Kinga Karlinger, Agnes Lannert, Eric Y. Yang, Vijay Nambi, Andrea Agnes Molnar, Viktor Berczi, Zsolt Garami

Introduction.- Atherosclerosis is an inflammatory process in which the artery wall thickens as a result of plaque deposition, but this process may be preceded by increased arterial stiffness. We sought to evaluate the influence of genetics and shared and unshared environmental components on the onset of atherosclerosis. Methods.- A total of 135 monozygotic (MZ) and 70 dizygotic (DZ) twin pairs (mean age 49 ± 16 years) underwent carotid intima media thickness (IMT; carotid analyzer) and arterial stiffness (augmentation index on brachial artery [Aixbra] pulse wave velocity on aorta [PWV ao]; TensioMed Arteriograph) measurements. Results.- Age-adjusted intraclass correlations were greater in MZ than in DZ pairs for proximal right common carotid artery (CCA; MZ = 0.19, DZ = 0.06), proximal and distal left CCA (MZ = 0.27, DZ = 0.06; MZ = 0.27, DZ = 0.13, respectively), and proximal left internal carotid artery (ICA; MZ = 0.39, DZ = -0.54), suggesting a moderate genetic effect. Heritability was estimated to be 18% (95% confidence interval [CI] = 3-33) for proximal right CCA, 26% and 27% for proximal and distal left CCA, respectively, and 38% (95% CI = 26-49) for proximal left ICA. Regarding distal right CCA and proximal right ICA, no genetic effects were detected. Age-adjusted intraclass correlation of Aixbra and PWVao were 0.65 (95% CI = 0.55-0.72) and 0.46 (95% CI = 0.33-0.57) in MZ, 0.42 (95% CI = 0.24-0.57) and 0.28 (95% CI = 0.08-0.47) in DZ pairs; heritability 45% (95% CI = 12-71%) and 42% (95% CI = 2-57%) adjusted by age, respectively. Conclusions.- The investigated parameters appeared to be only moderately influenced by genetic factors. Environmental factors of relevance for these measures appeared not to be shared within family but related to individual experience (e.g., smoking habits, diet, and physical activity). Atherosclerosis detection at an early stage is necessary for treatment to prevent serious complications such as stroke and heart attack.

Original languageEnglish
Pages (from-to)61-71
Number of pages11
JournalJournal for Vascular Ultrasound
Volume35
Issue number2
StatePublished - Jun 1 2011

Cite this

Standard

Twins lead to the prevention of atherosclerosis : Preliminary findings of international twin study 2009. / Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Stazi, Maria Antonietta; Medda, Emanuela; Cotichini, Rodolfo; Lucatelli, Pierleone; Boatta, Emanuele; Zini, Chiara; Baracchini, Claudio; Meneghetti, Giorgio; Nisticó, Lorenza; Fagnani, Corrado; Fanelli, Fabrizio; Giannoni, Maria Fabrizia; Gazzetti, Marianna; Osztovits, Janos; Jermendy, Gyorgy; Préda, István; Kiss, Róbert Gábor; Littvay, Levente; Metneki, Julia; Horvath, Tamas; Karlinger, Kinga; Lannert, Agnes; Yang, Eric Y.; Nambi, Vijay; Molnar, Andrea Agnes; Berczi, Viktor; Garami, Zsolt.

In: Journal for Vascular Ultrasound, Vol. 35, No. 2, 01.06.2011, p. 61-71.

Research output: Contribution to journalArticle

Harvard

Tarnoki, AD, Tarnoki, DL, Stazi, MA, Medda, E, Cotichini, R, Lucatelli, P, Boatta, E, Zini, C, Baracchini, C, Meneghetti, G, Nisticó, L, Fagnani, C, Fanelli, F, Giannoni, MF, Gazzetti, M, Osztovits, J, Jermendy, G, Préda, I, Kiss, RG, Littvay, L, Metneki, J, Horvath, T, Karlinger, K, Lannert, A, Yang, EY, Nambi, V, Molnar, AA, Berczi, V & Garami, Z 2011, 'Twins lead to the prevention of atherosclerosis: Preliminary findings of international twin study 2009' Journal for Vascular Ultrasound, vol. 35, no. 2, pp. 61-71.

APA

Tarnoki, A. D., Tarnoki, D. L., Stazi, M. A., Medda, E., Cotichini, R., Lucatelli, P., ... Garami, Z. (2011). Twins lead to the prevention of atherosclerosis: Preliminary findings of international twin study 2009. Journal for Vascular Ultrasound, 35(2), 61-71.

Vancouver

Tarnoki AD, Tarnoki DL, Stazi MA, Medda E, Cotichini R, Lucatelli P et al. Twins lead to the prevention of atherosclerosis: Preliminary findings of international twin study 2009. Journal for Vascular Ultrasound. 2011 Jun 1;35(2):61-71.

Author

Tarnoki, Adam Domonkos ; Tarnoki, David Laszlo ; Stazi, Maria Antonietta ; Medda, Emanuela ; Cotichini, Rodolfo ; Lucatelli, Pierleone ; Boatta, Emanuele ; Zini, Chiara ; Baracchini, Claudio ; Meneghetti, Giorgio ; Nisticó, Lorenza ; Fagnani, Corrado ; Fanelli, Fabrizio ; Giannoni, Maria Fabrizia ; Gazzetti, Marianna ; Osztovits, Janos ; Jermendy, Gyorgy ; Préda, István ; Kiss, Róbert Gábor ; Littvay, Levente ; Metneki, Julia ; Horvath, Tamas ; Karlinger, Kinga ; Lannert, Agnes ; Yang, Eric Y. ; Nambi, Vijay ; Molnar, Andrea Agnes ; Berczi, Viktor ; Garami, Zsolt. / Twins lead to the prevention of atherosclerosis : Preliminary findings of international twin study 2009. In: Journal for Vascular Ultrasound. 2011 ; Vol. 35, No. 2. pp. 61-71.

BibTeX

@article{5f8d1f1019cf45ea8cefe04699f8ff85,
title = "Twins lead to the prevention of atherosclerosis: Preliminary findings of international twin study 2009",
abstract = "Introduction.- Atherosclerosis is an inflammatory process in which the artery wall thickens as a result of plaque deposition, but this process may be preceded by increased arterial stiffness. We sought to evaluate the influence of genetics and shared and unshared environmental components on the onset of atherosclerosis. Methods.- A total of 135 monozygotic (MZ) and 70 dizygotic (DZ) twin pairs (mean age 49 ± 16 years) underwent carotid intima media thickness (IMT; carotid analyzer) and arterial stiffness (augmentation index on brachial artery [Aixbra] pulse wave velocity on aorta [PWV ao]; TensioMed Arteriograph) measurements. Results.- Age-adjusted intraclass correlations were greater in MZ than in DZ pairs for proximal right common carotid artery (CCA; MZ = 0.19, DZ = 0.06), proximal and distal left CCA (MZ = 0.27, DZ = 0.06; MZ = 0.27, DZ = 0.13, respectively), and proximal left internal carotid artery (ICA; MZ = 0.39, DZ = -0.54), suggesting a moderate genetic effect. Heritability was estimated to be 18{\%} (95{\%} confidence interval [CI] = 3-33) for proximal right CCA, 26{\%} and 27{\%} for proximal and distal left CCA, respectively, and 38{\%} (95{\%} CI = 26-49) for proximal left ICA. Regarding distal right CCA and proximal right ICA, no genetic effects were detected. Age-adjusted intraclass correlation of Aixbra and PWVao were 0.65 (95{\%} CI = 0.55-0.72) and 0.46 (95{\%} CI = 0.33-0.57) in MZ, 0.42 (95{\%} CI = 0.24-0.57) and 0.28 (95{\%} CI = 0.08-0.47) in DZ pairs; heritability 45{\%} (95{\%} CI = 12-71{\%}) and 42{\%} (95{\%} CI = 2-57{\%}) adjusted by age, respectively. Conclusions.- The investigated parameters appeared to be only moderately influenced by genetic factors. Environmental factors of relevance for these measures appeared not to be shared within family but related to individual experience (e.g., smoking habits, diet, and physical activity). Atherosclerosis detection at an early stage is necessary for treatment to prevent serious complications such as stroke and heart attack.",
author = "Tarnoki, {Adam Domonkos} and Tarnoki, {David Laszlo} and Stazi, {Maria Antonietta} and Emanuela Medda and Rodolfo Cotichini and Pierleone Lucatelli and Emanuele Boatta and Chiara Zini and Claudio Baracchini and Giorgio Meneghetti and Lorenza Nistic{\'o} and Corrado Fagnani and Fabrizio Fanelli and Giannoni, {Maria Fabrizia} and Marianna Gazzetti and Janos Osztovits and Gyorgy Jermendy and Istv{\'a}n Pr{\'e}da and Kiss, {R{\'o}bert G{\'a}bor} and Levente Littvay and Julia Metneki and Tamas Horvath and Kinga Karlinger and Agnes Lannert and Yang, {Eric Y.} and Vijay Nambi and Molnar, {Andrea Agnes} and Viktor Berczi and Zsolt Garami",
year = "2011",
month = "6",
day = "1",
language = "English",
volume = "35",
pages = "61--71",
journal = "Journal for Vascular Ultrasound",
issn = "1544-3167",
publisher = "Society of Vascular Ultrasound",
number = "2",

}

RIS

TY - JOUR

T1 - Twins lead to the prevention of atherosclerosis

T2 - Journal for Vascular Ultrasound

AU - Tarnoki, Adam Domonkos

AU - Tarnoki, David Laszlo

AU - Stazi, Maria Antonietta

AU - Medda, Emanuela

AU - Cotichini, Rodolfo

AU - Lucatelli, Pierleone

AU - Boatta, Emanuele

AU - Zini, Chiara

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Nisticó, Lorenza

AU - Fagnani, Corrado

AU - Fanelli, Fabrizio

AU - Giannoni, Maria Fabrizia

AU - Gazzetti, Marianna

AU - Osztovits, Janos

AU - Jermendy, Gyorgy

AU - Préda, István

AU - Kiss, Róbert Gábor

AU - Littvay, Levente

AU - Metneki, Julia

AU - Horvath, Tamas

AU - Karlinger, Kinga

AU - Lannert, Agnes

AU - Yang, Eric Y.

AU - Nambi, Vijay

AU - Molnar, Andrea Agnes

AU - Berczi, Viktor

AU - Garami, Zsolt

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Introduction.- Atherosclerosis is an inflammatory process in which the artery wall thickens as a result of plaque deposition, but this process may be preceded by increased arterial stiffness. We sought to evaluate the influence of genetics and shared and unshared environmental components on the onset of atherosclerosis. Methods.- A total of 135 monozygotic (MZ) and 70 dizygotic (DZ) twin pairs (mean age 49 ± 16 years) underwent carotid intima media thickness (IMT; carotid analyzer) and arterial stiffness (augmentation index on brachial artery [Aixbra] pulse wave velocity on aorta [PWV ao]; TensioMed Arteriograph) measurements. Results.- Age-adjusted intraclass correlations were greater in MZ than in DZ pairs for proximal right common carotid artery (CCA; MZ = 0.19, DZ = 0.06), proximal and distal left CCA (MZ = 0.27, DZ = 0.06; MZ = 0.27, DZ = 0.13, respectively), and proximal left internal carotid artery (ICA; MZ = 0.39, DZ = -0.54), suggesting a moderate genetic effect. Heritability was estimated to be 18% (95% confidence interval [CI] = 3-33) for proximal right CCA, 26% and 27% for proximal and distal left CCA, respectively, and 38% (95% CI = 26-49) for proximal left ICA. Regarding distal right CCA and proximal right ICA, no genetic effects were detected. Age-adjusted intraclass correlation of Aixbra and PWVao were 0.65 (95% CI = 0.55-0.72) and 0.46 (95% CI = 0.33-0.57) in MZ, 0.42 (95% CI = 0.24-0.57) and 0.28 (95% CI = 0.08-0.47) in DZ pairs; heritability 45% (95% CI = 12-71%) and 42% (95% CI = 2-57%) adjusted by age, respectively. Conclusions.- The investigated parameters appeared to be only moderately influenced by genetic factors. Environmental factors of relevance for these measures appeared not to be shared within family but related to individual experience (e.g., smoking habits, diet, and physical activity). Atherosclerosis detection at an early stage is necessary for treatment to prevent serious complications such as stroke and heart attack.

AB - Introduction.- Atherosclerosis is an inflammatory process in which the artery wall thickens as a result of plaque deposition, but this process may be preceded by increased arterial stiffness. We sought to evaluate the influence of genetics and shared and unshared environmental components on the onset of atherosclerosis. Methods.- A total of 135 monozygotic (MZ) and 70 dizygotic (DZ) twin pairs (mean age 49 ± 16 years) underwent carotid intima media thickness (IMT; carotid analyzer) and arterial stiffness (augmentation index on brachial artery [Aixbra] pulse wave velocity on aorta [PWV ao]; TensioMed Arteriograph) measurements. Results.- Age-adjusted intraclass correlations were greater in MZ than in DZ pairs for proximal right common carotid artery (CCA; MZ = 0.19, DZ = 0.06), proximal and distal left CCA (MZ = 0.27, DZ = 0.06; MZ = 0.27, DZ = 0.13, respectively), and proximal left internal carotid artery (ICA; MZ = 0.39, DZ = -0.54), suggesting a moderate genetic effect. Heritability was estimated to be 18% (95% confidence interval [CI] = 3-33) for proximal right CCA, 26% and 27% for proximal and distal left CCA, respectively, and 38% (95% CI = 26-49) for proximal left ICA. Regarding distal right CCA and proximal right ICA, no genetic effects were detected. Age-adjusted intraclass correlation of Aixbra and PWVao were 0.65 (95% CI = 0.55-0.72) and 0.46 (95% CI = 0.33-0.57) in MZ, 0.42 (95% CI = 0.24-0.57) and 0.28 (95% CI = 0.08-0.47) in DZ pairs; heritability 45% (95% CI = 12-71%) and 42% (95% CI = 2-57%) adjusted by age, respectively. Conclusions.- The investigated parameters appeared to be only moderately influenced by genetic factors. Environmental factors of relevance for these measures appeared not to be shared within family but related to individual experience (e.g., smoking habits, diet, and physical activity). Atherosclerosis detection at an early stage is necessary for treatment to prevent serious complications such as stroke and heart attack.

UR - http://www.scopus.com/inward/record.url?scp=79957937421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957937421&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 61

EP - 71

JO - Journal for Vascular Ultrasound

JF - Journal for Vascular Ultrasound

SN - 1544-3167

IS - 2

ER -

ID: 2943872