Twenty-five years of statins: Where do we go from here?

Antonio Gotto, Jennifer E. Moon

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

More than 25 years of clinical trial data have established statins as first-line therapy for the prevention and treatment of atherosclerotic cardiovascular disease. With regard to low-density lipoprotein cholesterol, a wealth of evidence indicates that 'lower is better,' although recent guidelines from the American College of Cardiology and the American Heart Association take a different approach. A variety of approved and experimental lipid-lowering agents may be used as supplements or alternatives to statin therapy in patient subgroups, including those with familial hypercholesterolemia, mixed dyslipidemia or statin intolerance. Strategies to achieve further reductions in low-density lipoprotein cholesterol, target high-density lipoprotein cholesterol and triglycerides or reduce inflammation may help address residual cardiovascular risk, although early lifestyle interventions are crucial to prevention strategies.

Original languageEnglish (US)
Pages (from-to)33-45
Number of pages13
JournalClinical Lipidology
Volume10
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • atherosclerotic cardiovascular disease
  • HDL-cholesterol
  • LDL-cholesterol
  • lipid-lowering therapy
  • prevention
  • statin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

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