TY - JOUR
T1 - Turning brain into blood
T2 - A hematopoietic fate adopted by adult neural stem cells in vivo
AU - Bjornson, Christopher R.R.
AU - Rietze, Rodney L.
AU - Reynolds, Brent A.
AU - Magli, M. Cristina
AU - Vescovi, Angelo L.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/1/22
Y1 - 1999/1/22
N2 - Stem cells are found in various organs where they participate in tissue homeostasis by replacing differentiated cells lost to physiological turnover or injury. An investigation was performed to determine whether stem cells are restricted to produce specific cell types, namely, those from the tissue in which they reside. After transplantation into irradiated hosts, genetically labeled neural stem cells were found to produce a variety of blood cell types including myeloid and lymphoid cells as well as early hematopoietic cells. Thus, neural stem cells appear to have a wider differentiation potential than previously thought.
AB - Stem cells are found in various organs where they participate in tissue homeostasis by replacing differentiated cells lost to physiological turnover or injury. An investigation was performed to determine whether stem cells are restricted to produce specific cell types, namely, those from the tissue in which they reside. After transplantation into irradiated hosts, genetically labeled neural stem cells were found to produce a variety of blood cell types including myeloid and lymphoid cells as well as early hematopoietic cells. Thus, neural stem cells appear to have a wider differentiation potential than previously thought.
UR - http://www.scopus.com/inward/record.url?scp=0033593654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033593654&partnerID=8YFLogxK
U2 - 10.1126/science.283.5401.534
DO - 10.1126/science.283.5401.534
M3 - Article
C2 - 9915700
AN - SCOPUS:0033593654
VL - 283
SP - 534
EP - 537
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
SN - 0036-8075
IS - 5401
ER -