Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for in Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy

Yuan Yong, Xiaju Cheng, Tao Bao, Mian Zu, Liang Yan, Wenyan Yin, Cuicui Ge, Dongliang Wang, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

290 Scopus citations

Abstract

Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumors is desirable but remains a great challenge. Here, we report a multifunctional nanomedicine based on WS2 quantum dots (QDs), which was prepared by a facile and "green" method through physical grinding and ultrasonication. The as-obtained WS2 QDs with small size (3 nm) possess not only significant X-ray computed tomography (CT)/photoaccoustic (PA) imaging signal enhancement but also remarkable photothermal therapy (PTT)/radiotherapy (RT) synergistic effect for tumor treatment. With CT/PA imaging and the synergistic effect between PTT and RT, the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of WS2 QDs. Moreover, hematoxylin and eosin staining, blood hematology, and biochemistry analysis revealed no noticeable toxicity of WS2 QDs in vitro and in vivo, which confirmed that WS2 QDs possess good biocompatibility. This multifunctional nanoparticle could play an important role in facilitating simultaneously multimodal imaging and synergistic therapy between PTT and RT to achieve better therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)12451-12463
Number of pages13
JournalACS Nano
Volume9
Issue number12
DOIs
StatePublished - Oct 23 2015

Keywords

  • WS quantum dots
  • X-ray computed tomography
  • photoaccoustic imaging
  • photothermal therapy
  • radiotherapy therapy
  • synergistic therapy

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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