TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES

F. T. Cordingley; A. V. Hoffbrand; H. E. Heslop; M. Turner; A. Bianchi; J. E. Reittie; A. Vyakarnam; A. Meager; M. K. Brenner

doi:10.1016/S0140-6736(88)91782-5

TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES

F. T. Cordingley, A. V. Hoffbrand, H. E. Heslop, M. Turner, A. Bianchi, J. E. Reittie, A. Vyakarnam, A. Meager, M. K. Brenner

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285 Scopus citations

Abstract

Recombinant tumour necrosis factor (TNF) promotes survival and induces proliferation in the tumour cells from two malignancies of B lymphocytes - hairy-cell leukaemia and B-chronic lymphocytic leukaemia. Culture with TNF also induces TNF mRNA and protein, so the cytokine may act as an autocrine tumour growth factor. These growth promoting effects are antagonised by alpha but not by gamma interferon.

Original language	English (US)
Pages (from-to)	969-971
Number of pages	3
Journal	The Lancet
Volume	331
Issue number	8592
DOIs	https://doi.org/10.1016/S0140-6736(88)91782-5
State	Published - Apr 30 1988

ASJC Scopus subject areas

General Medicine

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@article{6dbf92a6915845d39df9793d359064d7,

title = "TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES",

abstract = "Recombinant tumour necrosis factor (TNF) promotes survival and induces proliferation in the tumour cells from two malignancies of B lymphocytes - hairy-cell leukaemia and B-chronic lymphocytic leukaemia. Culture with TNF also induces TNF mRNA and protein, so the cytokine may act as an autocrine tumour growth factor. These growth promoting effects are antagonised by alpha but not by gamma interferon.",

author = "Cordingley, \{F. T.\} and Hoffbrand, \{A. V.\} and Heslop, \{H. E.\} and M. Turner and A. Bianchi and Reittie, \{J. E.\} and A. Vyakarnam and A. Meager and Brenner, \{M. K.\}",

note = "Funding Information: We thank Daryl Fernandes and David Ashford for help with the statistical analysis and Mrs P. M. Rudd for technical assistance. R. B. P., R. A. D., and T. W. R are members of the Oxford Glycobiology Unit, which is supported by the Monsanto Company. Correspondence should be addressed to T. W. R., Department of Biochemistry, University of Oxford, South Parks Road, Oxford OXl 3QU. Funding Information: EBV immunofluorescence, and Mrs Megan Evans for preparation of the typescript. F. T. C. is a recipient of an SAW Medical Research Fellowship (University of Western Australia). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1988",

month = apr,

day = "30",

doi = "10.1016/S0140-6736(88)91782-5",

language = "English (US)",

volume = "331",

pages = "969--971",

journal = "The Lancet",

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publisher = "Elsevier B.V.",

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T1 - TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES

AU - Cordingley, F. T.

AU - Hoffbrand, A. V.

AU - Heslop, H. E.

AU - Turner, M.

AU - Bianchi, A.

AU - Reittie, J. E.

AU - Vyakarnam, A.

AU - Meager, A.

AU - Brenner, M. K.

N1 - Funding Information: We thank Daryl Fernandes and David Ashford for help with the statistical analysis and Mrs P. M. Rudd for technical assistance. R. B. P., R. A. D., and T. W. R are members of the Oxford Glycobiology Unit, which is supported by the Monsanto Company. Correspondence should be addressed to T. W. R., Department of Biochemistry, University of Oxford, South Parks Road, Oxford OXl 3QU. Funding Information: EBV immunofluorescence, and Mrs Megan Evans for preparation of the typescript. F. T. C. is a recipient of an SAW Medical Research Fellowship (University of Western Australia). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1988/4/30

Y1 - 1988/4/30

N2 - Recombinant tumour necrosis factor (TNF) promotes survival and induces proliferation in the tumour cells from two malignancies of B lymphocytes - hairy-cell leukaemia and B-chronic lymphocytic leukaemia. Culture with TNF also induces TNF mRNA and protein, so the cytokine may act as an autocrine tumour growth factor. These growth promoting effects are antagonised by alpha but not by gamma interferon.

AB - Recombinant tumour necrosis factor (TNF) promotes survival and induces proliferation in the tumour cells from two malignancies of B lymphocytes - hairy-cell leukaemia and B-chronic lymphocytic leukaemia. Culture with TNF also induces TNF mRNA and protein, so the cytokine may act as an autocrine tumour growth factor. These growth promoting effects are antagonised by alpha but not by gamma interferon.

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U2 - 10.1016/S0140-6736(88)91782-5

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AN - SCOPUS:0023937119

SN - 0140-6736

VL - 331

SP - 969

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JO - The Lancet

JF - The Lancet

IS - 8592

ER -

TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES

Abstract

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