TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES

F. T. Cordingley, A. V. Hoffbrand, H. E. Heslop, M. Turner, A. Bianchi, J. E. Reittie, A. Vyakarnam, A. Meager, M. K. Brenner

Research output: Contribution to journalArticle

257 Scopus citations

Abstract

Recombinant tumour necrosis factor (TNF) promotes survival and induces proliferation in the tumour cells from two malignancies of B lymphocytes - hairy-cell leukaemia and B-chronic lymphocytic leukaemia. Culture with TNF also induces TNF mRNA and protein, so the cytokine may act as an autocrine tumour growth factor. These growth promoting effects are antagonised by alpha but not by gamma interferon.

Original languageEnglish (US)
Pages (from-to)969-971
Number of pages3
JournalThe Lancet
Volume331
Issue number8592
DOIs
StatePublished - Apr 30 1988

ASJC Scopus subject areas

  • Medicine(all)

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