Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

Lalit K. Golani, Adrianne Wallace-Povirk, Siobhan M. Deis, Jennifer Wong, Jiyuan Ke, Xin Gu, Sudhir Raghavan, Mike R. Wilson, Xinxin Li, Lisa Polin, Parker W. De Waal, Kathryn White, Juiwanna Kushner, Carrie O'Connor, Zhanjun Hou, H. Eric Xu, Karsten Melcher, Charles E. Dann, Larry H. Matherly, Aleem Gangjee

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