Tumor Microenvironment: Vascular and Extravascular Compartment

Rakesh K. Jain; John D. Martin; Vikash P. Chauhan; Dan G. Duda

doi:10.1016/B978-0-323-47674-4.00008-6

Tumor Microenvironment: Vascular and Extravascular Compartment

Rakesh K. Jain, John D. Martin, Vikash P. Chauhan, Dan G. Duda

Research output: Chapter in Book/Report/Conference proceeding › Chapter

10 Scopus citations

Abstract

A solid tumor is an organ composed of neoplastic cells and host stromal cells nourished by the vasculature made of endothelial cells-all embedded in an extracellular matrix. The interactions among these cells, their surrounding matrix, and their local microenvironment control the expression of various genes. The products encoded by these genes, in turn, control the pathophysiologic characteristics of the tumor. Tumor pathophysiology governs not only tumor growth, invasion, and metastasis but also the response to various therapies. This chapter discusses various pathophysiologic parameters that characterize the vascular and extravascular compartments of a tumor and the mechanisms governing the formation and function of these compartments.

Original language	English (US)
Title of host publication	Abeloff’s Clinical Oncology
Publisher	Elsevier
Pages	108-126.e7
ISBN (Electronic)	9780323476744
DOIs	https://doi.org/10.1016/B978-0-323-47674-4.00008-6
State	Published - Jan 1 2019

Keywords

Angiogenesis
Drug delivery
Therapeutic resistance
Tumor microenvironment

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-47674-4.00008-6

Cite this

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title = "Tumor Microenvironment: Vascular and Extravascular Compartment",

abstract = "A solid tumor is an organ composed of neoplastic cells and host stromal cells nourished by the vasculature made of endothelial cells-all embedded in an extracellular matrix. The interactions among these cells, their surrounding matrix, and their local microenvironment control the expression of various genes. The products encoded by these genes, in turn, control the pathophysiologic characteristics of the tumor. Tumor pathophysiology governs not only tumor growth, invasion, and metastasis but also the response to various therapies. This chapter discusses various pathophysiologic parameters that characterize the vascular and extravascular compartments of a tumor and the mechanisms governing the formation and function of these compartments.",

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author = "Jain, \{Rakesh K.\} and Martin, \{John D.\} and Chauhan, \{Vikash P.\} and Duda, \{Dan G.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2019",

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doi = "10.1016/B978-0-323-47674-4.00008-6",

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TY - CHAP

T1 - Tumor Microenvironment

T2 - Vascular and Extravascular Compartment

AU - Jain, Rakesh K.

AU - Martin, John D.

AU - Chauhan, Vikash P.

AU - Duda, Dan G.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A solid tumor is an organ composed of neoplastic cells and host stromal cells nourished by the vasculature made of endothelial cells-all embedded in an extracellular matrix. The interactions among these cells, their surrounding matrix, and their local microenvironment control the expression of various genes. The products encoded by these genes, in turn, control the pathophysiologic characteristics of the tumor. Tumor pathophysiology governs not only tumor growth, invasion, and metastasis but also the response to various therapies. This chapter discusses various pathophysiologic parameters that characterize the vascular and extravascular compartments of a tumor and the mechanisms governing the formation and function of these compartments.

AB - A solid tumor is an organ composed of neoplastic cells and host stromal cells nourished by the vasculature made of endothelial cells-all embedded in an extracellular matrix. The interactions among these cells, their surrounding matrix, and their local microenvironment control the expression of various genes. The products encoded by these genes, in turn, control the pathophysiologic characteristics of the tumor. Tumor pathophysiology governs not only tumor growth, invasion, and metastasis but also the response to various therapies. This chapter discusses various pathophysiologic parameters that characterize the vascular and extravascular compartments of a tumor and the mechanisms governing the formation and function of these compartments.

KW - Angiogenesis

KW - Drug delivery

KW - Therapeutic resistance

KW - Tumor microenvironment

UR - https://www.scopus.com/pages/publications/85078340090

UR - https://www.scopus.com/inward/citedby.url?scp=85078340090&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-47674-4.00008-6

DO - 10.1016/B978-0-323-47674-4.00008-6

M3 - Chapter

AN - SCOPUS:85078340090

SP - 108-126.e7

BT - Abeloff’s Clinical Oncology

PB - Elsevier

ER -

Tumor Microenvironment: Vascular and Extravascular Compartment

Abstract

Keywords

ASJC Scopus subject areas

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