Tumor growth modeling from the perspective of multiphase porous media mechanics

G. Sciumè, S. E. Shelton, W. G. Gray, C. T. Miller, F. Hussain, M. Ferrari, P. Decuzzi, B. A. Schrefler

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Multiphase porous media mechanics is used for modeling tumor growth, using governing equations obtained via the Thermodynamically Constrained Averaging Theory (TCAT). This approach incorporates the interaction of more phases than legacy tumor growth models. The tumor is treated as a multiphase system composed of an extracellular matrix, tumor cells which may become necrotic depending on nutrient level and pressure, healthy cells and an interstitial fluid which transports nutrients. The governing equations are numerically solved within a Finite Element framework for predicting the growth rate of the tumor mass, and of its individual components, as a function of the initial tumor-to-healthy cell ratio, nutrient concentration, and mechanical strain. Preliminary results are shown.

Original languageEnglish (US)
Pages (from-to)193-212
Number of pages20
JournalMCB Molecular and Cellular Biomechanics
Volume9
Issue number3
StatePublished - 2012

Keywords

  • Finite Elements
  • Necrosis
  • Porous media mechanics
  • TCAT
  • Tumor growth

ASJC Scopus subject areas

  • Cell Biology
  • Biophysics
  • Molecular Biology
  • Molecular Medicine

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