Tumor fibroblast specific activation of a hybrid ferritin nanocage-based optical probe for tumor microenvironment imaging

Tianjiao Ji, Ying Zhao, Jing Wang, Xin Zheng, Yanhua Tian, Yuliang Zhao, Guangjun Nie

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Ferritin-based FAP-α-responsive fluorescence nanoprobes could be activated immediately as they penetrate the tumor blood vessels and come across the FAP-α molecules on the membrane of CAFs in the tumor microenvironment instead of reaching a certain depth into tumor tissue to interact with tumor cells. This probe may become a promising nanomaterial for highly specific and sensitive tumor imaging through responding to the enzymes in the tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)2427-2431
Number of pages5
JournalSmall
Volume9
Issue number14
DOIs
StatePublished - Jul 22 2013

Keywords

  • cancer-associated fibroblasts
  • ferritin
  • fibroblast activation protein-α
  • imaging
  • nanotechnology

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

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