Tumor antigens and immune regulation in cancer immunotherapy

Rongfu Wang, Helen Yicheng Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The importance of T-cell-mediated antitumor immunity has been demonstrated in both animal models and human cancer immunotherapy. The identification of tumor antigens from various types of cancer has generated a resurgence of interest in immunotherapy for cancer and provides the stage to develop therapeutic cancer vaccines. However, recent clinical studies indicate that immunity generated by peptide or DC/peptide vaccines is not sufficient to eradicate cancer. One of the major factors for the weak and transient immune response is the presence of immune suppression in tumor microenvironment. Regulatory T cells and myeloid-derived suppressor cells are major cell types that are responsible for immune suppression. Novel strategies have been developed for enhancing T-cell responses against cancer by overcoming immune suppression. Combination of antigen-specific vaccines to stimulate effector T cells with anti-immune suppression provides opportunities for developing effective cancer vaccines.

Original languageEnglish (US)
Title of host publicationInnate Immune Regulation and Cancer Immunotherapy
PublisherSpringer New York
Number of pages20
ISBN (Electronic)9781441999146
ISBN (Print)9781441999139
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)


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