Tubulointerstitial nephritis in systemic lupus erythematosus: Innocent bystander or ominous presage

Sadhna Dhingra, Raza Qureshi, Abdul Abdellatif, Lillian Gaber, Luan Truong

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


SLE-associated tubulointerstitial injury (SLE TIN) is increasingly recognized in two forms, i.e., secondary and primary. The secondary form coexists with lupus glomerulonephritis, whereas the primary form develops against the background of no or mild glomerular or vascular involvement. Secondary SLE TIN is frequent, but its frequency and severity correlate with the class of the associated lupus glomerulonephritis (GN), being almost universal in Class IV lupus GN and less frequent in GN of other classes. Although the presence of underlying GN may mask its clinical manifestation, secondary SLE TIN has a major prognostic implication for the renal outcome. Yet, SLE TIN is not factored in the current therapyfocused International Society of Nephrology/Renal Pathology Society schema of renal lupus classification, and its management remains to be elucidated. The pathogenesis of secondary SLE TIN is either immunologic, i.e., the tubulointerstitial injury being mediated by SLE-related immunologic mechanisms akin to those responsible for lupus GN; or non-immunologic, i.e., a nonspecific tubulointerstitial injury secondary to any type of advanced glomerular lesion, regardless of etiology. Primary SLE TIN is rare with about 15 reported cases. It has a rather uniform and distinctive clinical manifestation including acute kidney injury with no or mild proteinuria. It responds well to steroid and usually carries a good prognosis. Its pathogenesis is almost certain immunologic, with immunoglobulin/complement deposits along the tubular basement membrane in each reported case. In spite of these profound clinical implications, the current review underlies a limited knowledge on the pathobiology of SLE TIN.

Original languageEnglish (US)
Pages (from-to)553-565
Number of pages13
JournalHistology and Histopathology
Issue number5
StatePublished - Jan 1 2014


  • Lupus glomerulonephritis
  • Mechanism
  • Primary lupus tubulointerstitial nephritis
  • Prognosis
  • Secondary lupus tubulointerstitial nephritis
  • Systemic lupus erythematosus
  • Treatment

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine


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