Tropical spastic paraparesis: Clinical, immunological, and virological studies in two patients from martinique

Marinos C. Dalakas, Gary Stone, Gregory Elder, Mauro Ceroni, David Madden, Gustavo C. Roman, John L. Sever

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Two patients from Martinique with tropical spastic paraparesis had antibodies to human T-lymphotropic virus type I (HTLV-I) in serum and spinal fluid but no antibodies to other retroviruses tested. They presented with spastic weakness of both lower extremities, hyperreflexia with upgoing toes, sphincteric dysfunction, and normal sensation. By means of agarose isoelectric focusing and selective immunoblotting we demonstrated an increased intrathecal synthesis of IgG antibodies to HTLV-I in the spinal fluid. Unique oligoclonal bands of IgG antibodies to HTLV-I were present in the cerebrospinal fluid. Using a battery of monoclonal antibodies we also found in these patients an increased number of circulating T cells that expressed activation markers. We conclude that the HTLV-I retrovirus associated with tropical spastic paraparesis has both lymphocytotropic and neurotropic properties.

Original languageEnglish (US)
Pages (from-to)S136-S142
JournalAnnals of Neurology
Volume23
Issue number1 S
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Tropical spastic paraparesis: Clinical, immunological, and virological studies in two patients from martinique'. Together they form a unique fingerprint.

Cite this