Trophic effects of skeletal muscle extracts on spinal cord cultures

Yasuo Iwasaki, Masao Kinoshita, Ken Ikeda, Stanley H. Appel, Scott S. Stewart

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A soluble extract of newborn rat muscle was added to cultures of dissociated embryonic spinal cord cells in order to determine the effect on their morphology. The processes per cell ratio, and the length of neurites were all enhanced by the presence of extract in ventral cord cell cultures, but not in dorsal cord cell cultures. It is possible that muscle-derived neurotrophic factors regulate the in vivo phenomenon of neuronal cell death. Interference with neuron-muscle trophic communication, either directly or indirectly, might lead to excessive loss of motor neurons. This mechanism may be important in the pathogenesis of amyotrophic lateral schlerosis.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalInternational Journal of Neuroscience
Issue number3-4
StatePublished - 1989


  • Motor neuron survival
  • Neurotrophic factor
  • Spinal cord cultures
  • Spinal cord outgrowth
  • Trophic effect

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Trophic effects of skeletal muscle extracts on spinal cord cultures'. Together they form a unique fingerprint.

Cite this