Trophic effect of angiotensin II, vasopressin and other peptides on the cultured ventral spinal cord of rat embryo

Yasuo Iwasaki; Masao Kinoshita; Ken Ikeda; Toshiya Shiojima; Teruyuki Kurihara; Stanley H. Appel

doi:10.1016/0022-510X(91)90158-4

Trophic effect of angiotensin II, vasopressin and other peptides on the cultured ventral spinal cord of rat embryo

Yasuo Iwasaki, Masao Kinoshita, Ken Ikeda, Toshiya Shiojima, Teruyuki Kurihara, Stanley H. Appel

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We studied trophic effects of angiotensin II, vasopressin, cholecystokinin, and oxytocin on explanted ventral spinal cord cultures from 13- and 14-day-old rat embryos. There was a significant neurite promoting effect of the spinal cord cultures by using angiotensin II, vasopressin, and cholecystokinin. Cholecystokinin had the most potent effect at any concentrations. The minimum effective concentration was 10 ⁸M in angiotensin II and vasopressin and 10^-12 M in cholecystokinin, respectively. The effect of angiotensin II and vasopressin was dependent on concentrations. However, the rate and grade of neurite appearance did not correlate with the concentrations of cholecystokinin. Oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II, vasopressin and cholecystokinin have neurotrophic effects on the ventral spinal cord in cultures, and may be candidates for therapeutic trials of amyotrophic lateral sclerosis.

Original language	English (US)
Pages (from-to)	151-155
Number of pages	5
Journal	Journal of the Neurological Sciences
Volume	103
Issue number	2
DOIs	https://doi.org/10.1016/0022-510X(91)90158-4
State	Published - Jun 1991
Externally published	Yes

Keywords

Amyotrophic lateral sclerosis
Angiotensin II
Cholecystokinin
Oxytocin
Vasopressin
Ventral spinal cord culture

ASJC Scopus subject areas

Neurology
Developmental Neuroscience
Neuroscience(all)
Surgery
Clinical Neurology
Aging

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10.1016/0022-510X(91)90158-4

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title = "Trophic effect of angiotensin II, vasopressin and other peptides on the cultured ventral spinal cord of rat embryo",

abstract = "We studied trophic effects of angiotensin II, vasopressin, cholecystokinin, and oxytocin on explanted ventral spinal cord cultures from 13- and 14-day-old rat embryos. There was a significant neurite promoting effect of the spinal cord cultures by using angiotensin II, vasopressin, and cholecystokinin. Cholecystokinin had the most potent effect at any concentrations. The minimum effective concentration was 10 8M in angiotensin II and vasopressin and 10-12 M in cholecystokinin, respectively. The effect of angiotensin II and vasopressin was dependent on concentrations. However, the rate and grade of neurite appearance did not correlate with the concentrations of cholecystokinin. Oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II, vasopressin and cholecystokinin have neurotrophic effects on the ventral spinal cord in cultures, and may be candidates for therapeutic trials of amyotrophic lateral sclerosis.",

keywords = "Amyotrophic lateral sclerosis, Angiotensin II, Cholecystokinin, Oxytocin, Vasopressin, Ventral spinal cord culture",

author = "Yasuo Iwasaki and Masao Kinoshita and Ken Ikeda and Toshiya Shiojima and Teruyuki Kurihara and Appel, {Stanley H.}",

year = "1991",

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doi = "10.1016/0022-510X(91)90158-4",

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T1 - Trophic effect of angiotensin II, vasopressin and other peptides on the cultured ventral spinal cord of rat embryo

AU - Iwasaki, Yasuo

AU - Kinoshita, Masao

AU - Ikeda, Ken

AU - Shiojima, Toshiya

AU - Kurihara, Teruyuki

AU - Appel, Stanley H.

PY - 1991/6

Y1 - 1991/6

N2 - We studied trophic effects of angiotensin II, vasopressin, cholecystokinin, and oxytocin on explanted ventral spinal cord cultures from 13- and 14-day-old rat embryos. There was a significant neurite promoting effect of the spinal cord cultures by using angiotensin II, vasopressin, and cholecystokinin. Cholecystokinin had the most potent effect at any concentrations. The minimum effective concentration was 10 8M in angiotensin II and vasopressin and 10-12 M in cholecystokinin, respectively. The effect of angiotensin II and vasopressin was dependent on concentrations. However, the rate and grade of neurite appearance did not correlate with the concentrations of cholecystokinin. Oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II, vasopressin and cholecystokinin have neurotrophic effects on the ventral spinal cord in cultures, and may be candidates for therapeutic trials of amyotrophic lateral sclerosis.

AB - We studied trophic effects of angiotensin II, vasopressin, cholecystokinin, and oxytocin on explanted ventral spinal cord cultures from 13- and 14-day-old rat embryos. There was a significant neurite promoting effect of the spinal cord cultures by using angiotensin II, vasopressin, and cholecystokinin. Cholecystokinin had the most potent effect at any concentrations. The minimum effective concentration was 10 8M in angiotensin II and vasopressin and 10-12 M in cholecystokinin, respectively. The effect of angiotensin II and vasopressin was dependent on concentrations. However, the rate and grade of neurite appearance did not correlate with the concentrations of cholecystokinin. Oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II, vasopressin and cholecystokinin have neurotrophic effects on the ventral spinal cord in cultures, and may be candidates for therapeutic trials of amyotrophic lateral sclerosis.

KW - Amyotrophic lateral sclerosis

KW - Angiotensin II

KW - Cholecystokinin

KW - Oxytocin

KW - Vasopressin

KW - Ventral spinal cord culture

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Trophic effect of angiotensin II, vasopressin and other peptides on the cultured ventral spinal cord of rat embryo

Abstract

Keywords

ASJC Scopus subject areas

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