Trophic effect of angiotensin II, vasopressin and other peptides on the cultured ventral spinal cord of rat embryo

Yasuo Iwasaki, Masao Kinoshita, Ken Ikeda, Toshiya Shiojima, Teruyuki Kurihara, Stanley H. Appel

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We studied trophic effects of angiotensin II, vasopressin, cholecystokinin, and oxytocin on explanted ventral spinal cord cultures from 13- and 14-day-old rat embryos. There was a significant neurite promoting effect of the spinal cord cultures by using angiotensin II, vasopressin, and cholecystokinin. Cholecystokinin had the most potent effect at any concentrations. The minimum effective concentration was 10 8M in angiotensin II and vasopressin and 10-12 M in cholecystokinin, respectively. The effect of angiotensin II and vasopressin was dependent on concentrations. However, the rate and grade of neurite appearance did not correlate with the concentrations of cholecystokinin. Oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II, vasopressin and cholecystokinin have neurotrophic effects on the ventral spinal cord in cultures, and may be candidates for therapeutic trials of amyotrophic lateral sclerosis.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalJournal of the Neurological Sciences
Volume103
Issue number2
DOIs
StatePublished - Jun 1991
Externally publishedYes

Keywords

  • Amyotrophic lateral sclerosis
  • Angiotensin II
  • Cholecystokinin
  • Oxytocin
  • Vasopressin
  • Ventral spinal cord culture

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Neuroscience(all)
  • Surgery
  • Clinical Neurology
  • Aging

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