"triple-punch" strategy for triple negative breast cancer therapy with minimized drug dosage and improved antitumor efficacy

Shishuai Su, Yanhua Tian, Yiye Li, Yanping Ding, Tianjiao Ji, Meiyu Wu, Yan Wu, Guangjun Nie

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Effective therapeutics against triple negative breast cancer (TNBC), which has no standard-of-care therapy, needs to be developed urgently. Here we demonstrated a strategy of integrating indocyanine green (ICG), paclitaxel (PTX), and survivin siRNA into one thermosensitive poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate)-co-2-(dimethylamino)ethyl methacrylate-b-poly(d,l-lactide-co-glycolide) (P (MEO2MA-co-OEGMA-co-DMAEMA)-b-PLGA) nanoparticle (NP-IPS) for triple-punch strategy against TNBC. The NP-IPS significantly enhanced the stability of ICG. Controlled release of the PTX in tumor regions was triggered by the hyperthermia produced by laser irradiated ICG. The NP-IPS exhibited remarkable antitumor efficacy (almost complete ablation of the tumor xenografts) due to the combinational effects of chemotherapy, photothermal therapy, and gene therapy with low drug dose (ICG, 0.32 μmol/kg; PTX, 0.54 μmol/kg; siRNA, 1.5 mg/kg) and minimal side effects. Taken together, our current study demonstrates a nanoplatform for triple-therapy, which reveals a promising strategy for TNBC treatment.

Original languageEnglish (US)
Pages (from-to)1367-1378
Number of pages12
JournalACS Nano
Volume9
Issue number2
DOIs
StatePublished - Feb 24 2015

Keywords

  • combination antitumor therapy
  • thermoresponsive
  • triple negative breast cancer

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

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