TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

Tao Liu, Qin Tang, Kunpeng Liu, Weihong Xie, Xin Liu, Huishan Wang, Rong Fu Wang, Jun Cui

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

The AIM2 inflammasome is a key cytosolic signaling complex that is activated by double-stranded DNA, leading to the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18. Dysregulated AIM2 inflammasome activity is associated with human inflammatory diseases and cancers, suggesting that its activity must be tightly regulated. However, the precise molecular mechanisms that control AIM2 levels and activity are still poorly understood. Here, we report tripartite motif 11 (TRIM11) as a key negative regulator of the AIM2 inflammasome. Upon DNA virus infection, TRIM11 binds to AIM2 via its PS domain and undergoes auto-polyubiquitination at K458 to promote an association between TRIM11 and the autophagic cargo receptor p62 to mediate AIM2 degradation via selective autophagy. These findings identify a role for TRIMs in AIM2 inflammasome activation where TRIM11 acts as a secondary receptor to deliver AIM2 to the autophagosomes for degradation in a p62-dependent manner.

Original languageEnglish (US)
Pages (from-to)1988-2002
Number of pages15
JournalCell Reports
Volume16
Issue number7
DOIs
StatePublished - Aug 16 2016

Keywords

  • AIM2 inflammasome
  • TRIM11
  • p62
  • protein degradation
  • selective autophagy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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