Tricuspid Transcatheter Edge-to-Edge Repair in Orthotopic Heart Transplantation Recipients

Chloe Kharsa; Isadora Sande Mathias; Mangesh Kritya; Gal Sella; Karl Abou Zeid; Joe Aoun; Arvin Bhimaraj; Ashrith Guha; Janardhana R. Gorthi; Nadeen N. Faza; Stephen H. Little; Marvin D. Atkins; Michael J. Reardon; Neal S. Kleiman; Sachin S. Goel

doi:10.1016/j.jaccas.2026.108462

Tricuspid Transcatheter Edge-to-Edge Repair in Orthotopic Heart Transplantation Recipients

Chloe Kharsa, Isadora Sande Mathias, Mangesh Kritya, Gal Sella, Karl Abou Zeid, Joe Aoun, Arvin Bhimaraj, Ashrith Guha, Janardhana R. Gorthi, Nadeen N. Faza, Stephen H. Little, Marvin D. Atkins, Michael J. Reardon, Neal S. Kleiman, Sachin S. Goel

Research output: Contribution to journal › Article › peer-review

Abstract

Tricuspid regurgitation in orthotopic heart transplantation recipients is a common complication that has been associated with poor outcomes. Surgical intervention carries a high risk in this population given prior sternotomy, immunosuppression, and comorbidities. We report a case series of 4 orthotopic heart transplantation recipients with severe symptomatic tricuspid regurgitation who were treated successfully with tricuspid transcatheter edge-to-edge repair. All patients demonstrated clinical and echocardiographic improvement postprocedure, with no procedural complications or rehospitalizations at short-term follow-up.

Original language	English (US)
Article number	108462
Pages (from-to)	108462
Journal	JACC: Case Reports
Volume	31
Issue number	25
DOIs	https://doi.org/10.1016/j.jaccas.2026.108462
State	Published - Jun 24 2026

Keywords

T-TEER
orthotopic heart transplantation
transcatheter valve intervention
tricuspid regurgitation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jaccas.2026.108462

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Kharsa, C., Mathias, I. S., Kritya, M., Sella, G., Zeid, K. A., Aoun, J., Bhimaraj, A., Guha, A., Gorthi, J. R., Faza, N. N., Little, S. H., Atkins, M. D., Reardon, M. J., Kleiman, N. S., & Goel, S. S. (2026). Tricuspid Transcatheter Edge-to-Edge Repair in Orthotopic Heart Transplantation Recipients. JACC: Case Reports, 31(25), 108462. Article 108462. https://doi.org/10.1016/j.jaccas.2026.108462

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title = "Tricuspid Transcatheter Edge-to-Edge Repair in Orthotopic Heart Transplantation Recipients",

abstract = "Tricuspid regurgitation in orthotopic heart transplantation recipients is a common complication that has been associated with poor outcomes. Surgical intervention carries a high risk in this population given prior sternotomy, immunosuppression, and comorbidities. We report a case series of 4 orthotopic heart transplantation recipients with severe symptomatic tricuspid regurgitation who were treated successfully with tricuspid transcatheter edge-to-edge repair. All patients demonstrated clinical and echocardiographic improvement postprocedure, with no procedural complications or rehospitalizations at short-term follow-up.",

keywords = "T-TEER, orthotopic heart transplantation, transcatheter valve intervention, tricuspid regurgitation",

author = "Chloe Kharsa and Mathias, \{Isadora Sande\} and Mangesh Kritya and Gal Sella and Zeid, \{Karl Abou\} and Joe Aoun and Arvin Bhimaraj and Ashrith Guha and Gorthi, \{Janardhana R.\} and Faza, \{Nadeen N.\} and Little, \{Stephen H.\} and Atkins, \{Marvin D.\} and Reardon, \{Michael J.\} and Kleiman, \{Neal S.\} and Goel, \{Sachin S.\}",

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doi = "10.1016/j.jaccas.2026.108462",

language = "English (US)",

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pages = "108462",

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T1 - Tricuspid Transcatheter Edge-to-Edge Repair in Orthotopic Heart Transplantation Recipients

AU - Kharsa, Chloe

AU - Mathias, Isadora Sande

AU - Kritya, Mangesh

AU - Sella, Gal

AU - Zeid, Karl Abou

AU - Aoun, Joe

AU - Bhimaraj, Arvin

AU - Guha, Ashrith

AU - Gorthi, Janardhana R.

AU - Faza, Nadeen N.

AU - Little, Stephen H.

AU - Atkins, Marvin D.

AU - Reardon, Michael J.

AU - Kleiman, Neal S.

AU - Goel, Sachin S.

PY - 2026/6/24

Y1 - 2026/6/24

N2 - Tricuspid regurgitation in orthotopic heart transplantation recipients is a common complication that has been associated with poor outcomes. Surgical intervention carries a high risk in this population given prior sternotomy, immunosuppression, and comorbidities. We report a case series of 4 orthotopic heart transplantation recipients with severe symptomatic tricuspid regurgitation who were treated successfully with tricuspid transcatheter edge-to-edge repair. All patients demonstrated clinical and echocardiographic improvement postprocedure, with no procedural complications or rehospitalizations at short-term follow-up.

AB - Tricuspid regurgitation in orthotopic heart transplantation recipients is a common complication that has been associated with poor outcomes. Surgical intervention carries a high risk in this population given prior sternotomy, immunosuppression, and comorbidities. We report a case series of 4 orthotopic heart transplantation recipients with severe symptomatic tricuspid regurgitation who were treated successfully with tricuspid transcatheter edge-to-edge repair. All patients demonstrated clinical and echocardiographic improvement postprocedure, with no procedural complications or rehospitalizations at short-term follow-up.

KW - T-TEER

KW - orthotopic heart transplantation

KW - transcatheter valve intervention

KW - tricuspid regurgitation

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SN - 2666-0849

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ER -

Tricuspid Transcatheter Edge-to-Edge Repair in Orthotopic Heart Transplantation Recipients

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Keywords

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