Trends in human papillomavirus-related oropharyngeal cancer in Israel

Moran Amit, Kaplan Ilana, Sharon Pelles Avraham, Yoav Binenbaum, Gideon Bachar, Salem Billan, Suliman Zaarura, Rakefet Czerninski, Matan Bar-Tov, Alexander Maly, Sharon Akrish, Ziv Gil

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background The role of human papillomavirus (HPV) infection in oropharyngeal cancer (SCC) is well established. The annual incidence of oropharyngeal SCC in Israel is considerably lower than that in the United States. The purpose of this study was to assess the rate of HPV-related oropharyngeal SCC in Israel. Methods The cohort included patients with oropharyngeal SCC who were treated during 1999 to 2011 in Israel. HPV typing was carried out using reverse hybridization and immunohistochemistry. Results Of the 74 patients analyzed, 25 (33.7%) had detectable HPV DNA. Patients in the HPV-positive group tended to be younger, with a higher rate of nodal metastases, and no history of smoking (p <.02). Conclusion This study demonstrated a rate of HPV-related oropharyngeal SCC in Israel as approximately 3-fold lower than in Western countries. Low exposure to HPV-16, a lower rate of transformation, to cancer or protective genetic factors may contribute to the lower rate of oropharyngeal SCC in Israel.

Original languageEnglish (US)
Pages (from-to)E274-E278
JournalHead and Neck
StatePublished - Apr 1 2016


  • head and neck
  • human papillomavirus
  • oropharynx or oropharyngeal carcinoma
  • prevalence

ASJC Scopus subject areas

  • Otorhinolaryngology


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