Trends in human papillomavirus-related oropharyngeal cancer in Israel

Moran Amit; Kaplan Ilana; Sharon Pelles Avraham; Yoav Binenbaum; Gideon Bachar; Salem Billan; Suliman Zaarura; Rakefet Czerninski; Matan Bar-Tov; Alexander Maly; Sharon Akrish; Ziv Gil

doi:10.1002/hed.23985

Trends in human papillomavirus-related oropharyngeal cancer in Israel

Moran Amit, Kaplan Ilana, Sharon Pelles Avraham, Yoav Binenbaum, Gideon Bachar, Salem Billan, Suliman Zaarura, Rakefet Czerninski, Matan Bar-Tov, Alexander Maly, Sharon Akrish, Ziv Gil

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background The role of human papillomavirus (HPV) infection in oropharyngeal cancer (SCC) is well established. The annual incidence of oropharyngeal SCC in Israel is considerably lower than that in the United States. The purpose of this study was to assess the rate of HPV-related oropharyngeal SCC in Israel. Methods The cohort included patients with oropharyngeal SCC who were treated during 1999 to 2011 in Israel. HPV typing was carried out using reverse hybridization and immunohistochemistry. Results Of the 74 patients analyzed, 25 (33.7%) had detectable HPV DNA. Patients in the HPV-positive group tended to be younger, with a higher rate of nodal metastases, and no history of smoking (p <.02). Conclusion This study demonstrated a rate of HPV-related oropharyngeal SCC in Israel as approximately 3-fold lower than in Western countries. Low exposure to HPV-16, a lower rate of transformation, to cancer or protective genetic factors may contribute to the lower rate of oropharyngeal SCC in Israel.

Original language	English (US)
Pages (from-to)	E274-E278
Journal	Head and Neck
Volume	38
DOIs	https://doi.org/10.1002/hed.23985
State	Published - Apr 1 2016

Keywords

head and neck
human papillomavirus
oropharynx or oropharyngeal carcinoma
prevalence

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.23985

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title = "Trends in human papillomavirus-related oropharyngeal cancer in Israel",

abstract = "Background The role of human papillomavirus (HPV) infection in oropharyngeal cancer (SCC) is well established. The annual incidence of oropharyngeal SCC in Israel is considerably lower than that in the United States. The purpose of this study was to assess the rate of HPV-related oropharyngeal SCC in Israel. Methods The cohort included patients with oropharyngeal SCC who were treated during 1999 to 2011 in Israel. HPV typing was carried out using reverse hybridization and immunohistochemistry. Results Of the 74 patients analyzed, 25 (33.7%) had detectable HPV DNA. Patients in the HPV-positive group tended to be younger, with a higher rate of nodal metastases, and no history of smoking (p <.02). Conclusion This study demonstrated a rate of HPV-related oropharyngeal SCC in Israel as approximately 3-fold lower than in Western countries. Low exposure to HPV-16, a lower rate of transformation, to cancer or protective genetic factors may contribute to the lower rate of oropharyngeal SCC in Israel.",

keywords = "head and neck, human papillomavirus, oropharynx or oropharyngeal carcinoma, prevalence",

author = "Moran Amit and Kaplan Ilana and Avraham, {Sharon Pelles} and Yoav Binenbaum and Gideon Bachar and Salem Billan and Suliman Zaarura and Rakefet Czerninski and Matan Bar-Tov and Alexander Maly and Sharon Akrish and Ziv Gil",

note = "Funding Information: This research was supported by the Weizmann Institute TASMC Joint Grant, the ICRF Barbara S. Goodman endowed research career development award (2011-601-BGPC), and a grant from the U.S.-Israel Binational Science Foundation. Publisher Copyright: {\textcopyright} 2015 Wiley Periodicals, Inc..",

year = "2016",

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doi = "10.1002/hed.23985",

language = "English (US)",

volume = "38",

pages = "E274--E278",

journal = "Head and Neck",

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T1 - Trends in human papillomavirus-related oropharyngeal cancer in Israel

AU - Amit, Moran

AU - Ilana, Kaplan

AU - Avraham, Sharon Pelles

AU - Binenbaum, Yoav

AU - Bachar, Gideon

AU - Billan, Salem

AU - Zaarura, Suliman

AU - Czerninski, Rakefet

AU - Bar-Tov, Matan

AU - Maly, Alexander

AU - Akrish, Sharon

AU - Gil, Ziv

N1 - Funding Information: This research was supported by the Weizmann Institute TASMC Joint Grant, the ICRF Barbara S. Goodman endowed research career development award (2011-601-BGPC), and a grant from the U.S.-Israel Binational Science Foundation. Publisher Copyright: © 2015 Wiley Periodicals, Inc..

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background The role of human papillomavirus (HPV) infection in oropharyngeal cancer (SCC) is well established. The annual incidence of oropharyngeal SCC in Israel is considerably lower than that in the United States. The purpose of this study was to assess the rate of HPV-related oropharyngeal SCC in Israel. Methods The cohort included patients with oropharyngeal SCC who were treated during 1999 to 2011 in Israel. HPV typing was carried out using reverse hybridization and immunohistochemistry. Results Of the 74 patients analyzed, 25 (33.7%) had detectable HPV DNA. Patients in the HPV-positive group tended to be younger, with a higher rate of nodal metastases, and no history of smoking (p <.02). Conclusion This study demonstrated a rate of HPV-related oropharyngeal SCC in Israel as approximately 3-fold lower than in Western countries. Low exposure to HPV-16, a lower rate of transformation, to cancer or protective genetic factors may contribute to the lower rate of oropharyngeal SCC in Israel.

AB - Background The role of human papillomavirus (HPV) infection in oropharyngeal cancer (SCC) is well established. The annual incidence of oropharyngeal SCC in Israel is considerably lower than that in the United States. The purpose of this study was to assess the rate of HPV-related oropharyngeal SCC in Israel. Methods The cohort included patients with oropharyngeal SCC who were treated during 1999 to 2011 in Israel. HPV typing was carried out using reverse hybridization and immunohistochemistry. Results Of the 74 patients analyzed, 25 (33.7%) had detectable HPV DNA. Patients in the HPV-positive group tended to be younger, with a higher rate of nodal metastases, and no history of smoking (p <.02). Conclusion This study demonstrated a rate of HPV-related oropharyngeal SCC in Israel as approximately 3-fold lower than in Western countries. Low exposure to HPV-16, a lower rate of transformation, to cancer or protective genetic factors may contribute to the lower rate of oropharyngeal SCC in Israel.

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KW - human papillomavirus

KW - oropharynx or oropharyngeal carcinoma

KW - prevalence

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Trends in human papillomavirus-related oropharyngeal cancer in Israel

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