Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US

Jamalena Thompson, Collins Onyenaka, Emmanuella Oduguwa, Deepa Dongarwar, Sumaya Gendra, Vidella Coker, Seun Kutse, Mayra Blanco, Onyinye Nwangwu, Charlee King, Elza Enamorado, Oluwatoyin Bakare, Veronica B. Ajewole, Kiara K. Spooner, Jason L. Salemi, Muktar H. Aliyu, Hamisu M. Salihu, Omonike A. Olaleye

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Preeclampsia and HIV account for a significant proportion of the global burden of disease and pose severe maternal–fetal risks. There is a dearth of literature regarding racial/ethnic disparities in preeclampsia associated with HIV/AIDS in the US. Methods: We retrospectively analyzed data from the National Inpatient Sample (NIS) database from 2002 to 2015 on a cohort of hospitalized pregnant women with or without preeclampsia and HIV. Joinpoint regression models were used to identify trends in the rates of preeclampsia among pregnant women living with or without HIV, stratified by race/ethnicity over the study period. We also assessed the association between preeclampsia and various socio-demographic factors. Results: We analyzed over 60 million pregnancy-related hospitalizations, of which 3665 had diagnoses of preeclampsia and HIV, corresponding to a rate of 0.61 per 10,000. There was an increasing trend in the diagnosis of preeclampsia among hospitalized, pregnant women without HIV across each racial/ethnic category. The highest prevalence of preeclampsia was among non-Hispanic (NH) Blacks, regardless of HIV status. Conclusion: The increase in rates of pre-eclampsia between 2002 and 2015 was mostly noted among pregnant women without HIV. Regardless of HIV status, NH-Blacks experienced the highest discharge prevalence of preeclampsia.

Original languageEnglish (US)
Pages (from-to)670-677
Number of pages8
JournalJournal of Racial and Ethnic Health Disparities
Issue number3
StatePublished - Jun 2021


  • HIV
  • Maternal-fetal health
  • Preeclampsia
  • Pregnancy
  • Racial disparities

ASJC Scopus subject areas

  • Health(social science)
  • Anthropology
  • Sociology and Political Science
  • Health Policy
  • Public Health, Environmental and Occupational Health


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