Treatment options for atypical optic neuritis

Amina Malik, Maryam Ahmed, Karl Golnik

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Context: Optic neuritis (ON) is defined as inflammation of the optic nerve and can have various etiologies. The most common presentation in the US is demyelinating, or «typical» ON, usually associated with multiple sclerosis. This is in contrast to «atypical» causes of ON, which differ in their clinical presentation, management, and prognosis. These atypical cases are characterized by lack of eye pain, exudates, and hemorrhages on exam, very severe, bilateral or progressive visual loss, or with failure to recover vision. Aims: The aim was to describe the clinical presentations of atypical ON and their treatments. Settings and Design: Review article. Materials and Methods: Literature review. Results: Types of atypical ON identified include neuromyelitis optica, autoimmune optic neuropathy, chronic relapsing inflammatory optic neuropathy, idiopathic recurrent neuroretinitis, and optic neuropathy associated with systemic diseases. Atypical ON usually requires corticosteroid treatment and often will require aggressive immunosuppression. Conclusions: Unlike demyelinating ON, atypical ON requires treatment to preserve vision.

Original languageEnglish (US)
Pages (from-to)982-984
Number of pages3
JournalIndian Journal of Ophthalmology
Issue number10
StatePublished - Oct 1 2014


  • Atypical optic neuritis
  • autoimmunity
  • multiple sclerosis
  • neuromyelitis optica
  • neuroretinitis
  • optic neuritis
  • optic neuropathy

ASJC Scopus subject areas

  • Ophthalmology


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