Treatment of vascular dementia - Evidence from clinical trials with cholinesterase inhibitors

Timo Erkinjuntti, Gustavo Román, Serge Gauthier

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Cerebrovascular disease (CVD), as well as secondary ischemic brain injury from cardiovascular disease, are common causes of dementia and cognitive decline in the elderly. In addition, CVD frequently contributes to cognitive loss in patients with Alzheimer's disease (AD). Progress in understanding the pathogenetic mechanism involved in vascular cognitive impairment (VCI) and vascular dementia (VaD) has resulted in promising treatments of these conditions. Cholinergic deficits in VaD are due to ischemia of basal forebrain nuclei and of cholinergic pathways and can be treated with the use of the cholinesterase inhibitor agents used in AD. Controlled clinical trials with donepezil, galantamine and rivastigmine in VaD, as well as in patients with AD plus CVD, have demonstrated improvements in cognition, behavior and activities of daily living.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalJournal of the Neurological Sciences
Volume226
Issue number1-2 SPEC.ISS.
DOIs
StatePublished - Nov 15 2004

Keywords

  • Alzheimer's disease
  • Cholinesterase inhibitors
  • Vascular dementia

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

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