TY - JOUR
T1 - Treatment of vascular dementia - Evidence from clinical trials with cholinesterase inhibitors
AU - Erkinjuntti, Timo
AU - Román, Gustavo
AU - Gauthier, Serge
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/7
Y1 - 2004/7
N2 - Cerebrovascular disease (CVD), as well as secondary ischemic brain injury from cardiovascular disease, are common causes of dementia and cognitive decline in the elderly. Also, CVD frequently contributes to cognitive loss in patients with Alzheimer's disease (AD). Progress in understanding the pathogenetic mechanism involved in vascular cognitive impairment and vascular dementia (VaD) has resulted in promising treatments of these conditions. Cholinergic deficits in VaD are due to ischemia of basal forebrain nuclei and of cholinergic pathways and can be treated with the use of the cholinesterase inhibitors used in AD. Controlled clinical trials with donepezil, galantamine, and rivastigmine in VaD, as well as in patients with AD plus CVD, have demostrated improvement in cognition, behavior and activites of daily living.
AB - Cerebrovascular disease (CVD), as well as secondary ischemic brain injury from cardiovascular disease, are common causes of dementia and cognitive decline in the elderly. Also, CVD frequently contributes to cognitive loss in patients with Alzheimer's disease (AD). Progress in understanding the pathogenetic mechanism involved in vascular cognitive impairment and vascular dementia (VaD) has resulted in promising treatments of these conditions. Cholinergic deficits in VaD are due to ischemia of basal forebrain nuclei and of cholinergic pathways and can be treated with the use of the cholinesterase inhibitors used in AD. Controlled clinical trials with donepezil, galantamine, and rivastigmine in VaD, as well as in patients with AD plus CVD, have demostrated improvement in cognition, behavior and activites of daily living.
KW - Cerebrovascular disease
KW - Cholinesterase inhibitors
KW - Dementia
KW - Elderly
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=3042750659&partnerID=8YFLogxK
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U2 - 10.1179/01610425017631
DO - 10.1179/01610425017631
M3 - Article
C2 - 15265282
AN - SCOPUS:3042750659
VL - 26
SP - 603
EP - 605
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 5
ER -