Abstract
Amoxicillin plus clavulanic acid (A-CA), a combination potentially effective against beta-lactamase-producing bacteria, was compared against cefaclor (C) in a double-blind randomized trial in 91 children (46 A-CA, 45 C) with skin and soft-tissue infections. Types of infections included: moderate to severe impetigo 26, abscess 16, cellulitis 13, and five others affecting 9 subjects. Microorganisms included Staphylococcus aureus 51, Streptococcus pyogenes 24, and 9 isolates of 4 species of Gram-negative bacilli. Clinical cure was achieved in 36 of 37 children (97%) who received A-CA and in all who received C; bacteriologic cure was achieved in all patients. Side effects occurred in 2 children receiving A-CA and 4 receiving C.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 747-753 |
| Number of pages | 7 |
| Journal | Current Therapeutic Research - Clinical and Experimental |
| Volume | 37 |
| Issue number | 4 |
| State | Published - Jan 1 1985 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Fingerprint
Dive into the research topics of 'Treatment of soft-tissue infections in children with amoxicillin-clavulanic acid combination or cefaclor'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS