Treatment of soft-tissue infections in children with amoxicillin-clavulanic acid combination or cefaclor

W. L. Risser; Sheldon Kaplan; Edward Mason

Treatment of soft-tissue infections in children with amoxicillin-clavulanic acid combination or cefaclor

W. L. Risser, Sheldon Kaplan, Edward Mason

Research Institute

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2 Scopus citations

Abstract

Amoxicillin plus clavulanic acid (A-CA), a combination potentially effective against beta-lactamase-producing bacteria, was compared against cefaclor (C) in a double-blind randomized trial in 91 children (46 A-CA, 45 C) with skin and soft-tissue infections. Types of infections included: moderate to severe impetigo 26, abscess 16, cellulitis 13, and five others affecting 9 subjects. Microorganisms included Staphylococcus aureus 51, Streptococcus pyogenes 24, and 9 isolates of 4 species of Gram-negative bacilli. Clinical cure was achieved in 36 of 37 children (97%) who received A-CA and in all who received C; bacteriologic cure was achieved in all patients. Side effects occurred in 2 children receiving A-CA and 4 receiving C.

Original language	English (US)
Pages (from-to)	747-753
Number of pages	7
Journal	Current Therapeutic Research - Clinical and Experimental
Volume	37
Issue number	4
State	Published - Jan 1 1985

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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title = "Treatment of soft-tissue infections in children with amoxicillin-clavulanic acid combination or cefaclor",

abstract = "Amoxicillin plus clavulanic acid (A-CA), a combination potentially effective against beta-lactamase-producing bacteria, was compared against cefaclor (C) in a double-blind randomized trial in 91 children (46 A-CA, 45 C) with skin and soft-tissue infections. Types of infections included: moderate to severe impetigo 26, abscess 16, cellulitis 13, and five others affecting 9 subjects. Microorganisms included Staphylococcus aureus 51, Streptococcus pyogenes 24, and 9 isolates of 4 species of Gram-negative bacilli. Clinical cure was achieved in 36 of 37 children (97%) who received A-CA and in all who received C; bacteriologic cure was achieved in all patients. Side effects occurred in 2 children receiving A-CA and 4 receiving C.",

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N2 - Amoxicillin plus clavulanic acid (A-CA), a combination potentially effective against beta-lactamase-producing bacteria, was compared against cefaclor (C) in a double-blind randomized trial in 91 children (46 A-CA, 45 C) with skin and soft-tissue infections. Types of infections included: moderate to severe impetigo 26, abscess 16, cellulitis 13, and five others affecting 9 subjects. Microorganisms included Staphylococcus aureus 51, Streptococcus pyogenes 24, and 9 isolates of 4 species of Gram-negative bacilli. Clinical cure was achieved in 36 of 37 children (97%) who received A-CA and in all who received C; bacteriologic cure was achieved in all patients. Side effects occurred in 2 children receiving A-CA and 4 receiving C.

AB - Amoxicillin plus clavulanic acid (A-CA), a combination potentially effective against beta-lactamase-producing bacteria, was compared against cefaclor (C) in a double-blind randomized trial in 91 children (46 A-CA, 45 C) with skin and soft-tissue infections. Types of infections included: moderate to severe impetigo 26, abscess 16, cellulitis 13, and five others affecting 9 subjects. Microorganisms included Staphylococcus aureus 51, Streptococcus pyogenes 24, and 9 isolates of 4 species of Gram-negative bacilli. Clinical cure was achieved in 36 of 37 children (97%) who received A-CA and in all who received C; bacteriologic cure was achieved in all patients. Side effects occurred in 2 children receiving A-CA and 4 receiving C.

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