Amoxicillin plus clavulanic acid (A-CA), a combination potentially effective against beta-lactamase-producing bacteria, was compared against cefaclor (C) in a double-blind randomized trial in 91 children (46 A-CA, 45 C) with skin and soft-tissue infections. Types of infections included: moderate to severe impetigo 26, abscess 16, cellulitis 13, and five others affecting 9 subjects. Microorganisms included Staphylococcus aureus 51, Streptococcus pyogenes 24, and 9 isolates of 4 species of Gram-negative bacilli. Clinical cure was achieved in 36 of 37 children (97%) who received A-CA and in all who received C; bacteriologic cure was achieved in all patients. Side effects occurred in 2 children receiving A-CA and 4 receiving C.
|Original language||English (US)|
|Number of pages||7|
|Journal||Current Therapeutic Research - Clinical and Experimental|
|State||Published - Jan 1 1985|
ASJC Scopus subject areas
- Pharmacology (medical)