TY - JOUR
T1 - Treatment of soft-tissue infections in children with amoxicillin-clavulanic acid combination or cefaclor
AU - Risser, W. L.
AU - Kaplan, Sheldon
AU - Mason, Edward
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Amoxicillin plus clavulanic acid (A-CA), a combination potentially effective against beta-lactamase-producing bacteria, was compared against cefaclor (C) in a double-blind randomized trial in 91 children (46 A-CA, 45 C) with skin and soft-tissue infections. Types of infections included: moderate to severe impetigo 26, abscess 16, cellulitis 13, and five others affecting 9 subjects. Microorganisms included Staphylococcus aureus 51, Streptococcus pyogenes 24, and 9 isolates of 4 species of Gram-negative bacilli. Clinical cure was achieved in 36 of 37 children (97%) who received A-CA and in all who received C; bacteriologic cure was achieved in all patients. Side effects occurred in 2 children receiving A-CA and 4 receiving C.
AB - Amoxicillin plus clavulanic acid (A-CA), a combination potentially effective against beta-lactamase-producing bacteria, was compared against cefaclor (C) in a double-blind randomized trial in 91 children (46 A-CA, 45 C) with skin and soft-tissue infections. Types of infections included: moderate to severe impetigo 26, abscess 16, cellulitis 13, and five others affecting 9 subjects. Microorganisms included Staphylococcus aureus 51, Streptococcus pyogenes 24, and 9 isolates of 4 species of Gram-negative bacilli. Clinical cure was achieved in 36 of 37 children (97%) who received A-CA and in all who received C; bacteriologic cure was achieved in all patients. Side effects occurred in 2 children receiving A-CA and 4 receiving C.
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M3 - Article
AN - SCOPUS:0021839901
VL - 37
SP - 747
EP - 753
JO - Current Therapeutic Research - Clinical and Experimental
JF - Current Therapeutic Research - Clinical and Experimental
SN - 0011-393X
IS - 4
ER -