Treatment of restless legs syndrome and periodic limb movements

Research output: Chapter in Book/Report/Conference proceedingChapter


Restless legs syndrome (RLS) is a common neurological condition defined by (1) an urge to move the legs, (2) worsening with inactivity, (3) improvement with movement, and (4) worsening at night. It effects women more than men and is most common in Northern Europeans. There is a strong genetic component, but other conditions including systemic iron deficiency, renal failure, and pregnancy also cause RLS symptoms. The main pathology is reduction in brain iron stores, even in the setting of normal serum iron measures. First-line treatments are dopamine agonists and alpha-2-delta blockers. Additional treatments include opioids and intravenous iron.

Original languageEnglish (US)
Title of host publicationCurrent Clinical Neurology
PublisherHumana Press
Number of pages3
StatePublished - Jan 1 2019

Publication series

NameCurrent Clinical Neurology
ISSN (Print)1559-0585


  • Augmentation
  • Dopaminergics
  • Periodic limb movements
  • Restless legs syndrome

ASJC Scopus subject areas

  • Clinical Neurology


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