Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium

Bo Shen, Gursimran S. Kochhar, David T. Rubin, Sunanda V. Kane, Udayakumar Navaneethan, Charles N. Bernstein, Raymond K. Cross, Akira Sugita, Jason Schairer, Ravi P. Kiran, Philip Fleshner, James T. McCormick, André D'Hoore, Samir A. Shah, Francis A. Farraye, Revital Kariv, Xiuli Liu, Joel Rosh, Shannon Chang, Ellen ScherlDavid A. Schwartz, Paulo Gustavo Kotze, David H. Bruining, Jessica Philpott, Bincy Abraham, Jonathan Segal, Rocio Sedano, Maia Kayal, Stuart Bentley-Hibbert, Dino Tarabar, Sandra El-Hachem, Priya Sehgal, Joseph A. Picoraro, Séverine Vermeire, William J. Sandborn, Mark S. Silverberg, Darrell S. Pardi

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Pouchitis, Crohn's disease of the pouch, cuffitis, polyps, and extraintestinal manifestations of inflammatory bowel disease are common inflammatory disorders of the ileal pouch. Acute pouchitis is treated with oral antibiotics and chronic pouchitis often requires anti-inflammatory therapy, including the use of biologics. Aetiological factors for secondary pouchitis should be evaluated and managed accordingly. Crohn's disease of the pouch is usually treated with biologics and its stricturing and fistulising complications can be treated with endoscopy or surgery. The underlying cause of cuffitis determines treatment strategies. Endoscopic polypectomy is recommended for large, symptomatic inflammatory polyps and polyps in the cuff. The management principles of extraintestinal manifestations of inflammatory bowel disease in patients with pouches are similar to those in patients without pouches.

Original languageEnglish (US)
Pages (from-to)69-95
Number of pages27
JournalThe Lancet Gastroenterology and Hepatology
Volume7
Issue number1
DOIs
StatePublished - Jan 2022

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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