Treatment of multidrug-resistant vancomycin-resistant enterococcus faecium hardware-associated vertebral osteomyelitis with oritavancin plus ampicillin

Samira Dahesh; Brian Wong; Victor Nizet; George Sakoulas; Truc T. Tran; Samuel L. Aitken

doi:10.1128/AAC.02622-18

Treatment of multidrug-resistant vancomycin-resistant enterococcus faecium hardware-associated vertebral osteomyelitis with oritavancin plus ampicillin

Samira Dahesh, Brian Wong, Victor Nizet, George Sakoulas, Truc T. Tran, Samuel L. Aitken

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Weekly oritavancin plus ampicillin continuous infusion combination therapy was used to successfully treat a deep spine vancomycin-resistant Enterococcus faecium infection associated with hardware. Checkerboard and time-kill assays confirmed synergy between these two antibiotics. Further synergies of oritavancin and ampicillin with rifampin or the endogenous human antimicrobial peptide cathelicidin LL-37 were demonstrated.

Original language	English (US)
Article number	e02622-18
Journal	Antimicrobial Agents and Chemotherapy
Volume	63
Issue number	7
DOIs	https://doi.org/10.1128/AAC.02622-18
State	Published - 2019

Keywords

Ampicillin
Oritavancin
Vancomycin-resistant Enterococcus faecium

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.02622-18

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title = "Treatment of multidrug-resistant vancomycin-resistant enterococcus faecium hardware-associated vertebral osteomyelitis with oritavancin plus ampicillin",

abstract = "Weekly oritavancin plus ampicillin continuous infusion combination therapy was used to successfully treat a deep spine vancomycin-resistant Enterococcus faecium infection associated with hardware. Checkerboard and time-kill assays confirmed synergy between these two antibiotics. Further synergies of oritavancin and ampicillin with rifampin or the endogenous human antimicrobial peptide cathelicidin LL-37 were demonstrated.",

keywords = "Ampicillin, Oritavancin, Vancomycin-resistant Enterococcus faecium",

author = "Samira Dahesh and Brian Wong and Victor Nizet and George Sakoulas and Tran, \{Truc T.\} and Aitken, \{Samuel L.\}",

year = "2019",

doi = "10.1128/AAC.02622-18",

language = "English (US)",

volume = "63",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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T1 - Treatment of multidrug-resistant vancomycin-resistant enterococcus faecium hardware-associated vertebral osteomyelitis with oritavancin plus ampicillin

AU - Dahesh, Samira

AU - Wong, Brian

AU - Nizet, Victor

AU - Sakoulas, George

AU - Tran, Truc T.

AU - Aitken, Samuel L.

PY - 2019

Y1 - 2019

N2 - Weekly oritavancin plus ampicillin continuous infusion combination therapy was used to successfully treat a deep spine vancomycin-resistant Enterococcus faecium infection associated with hardware. Checkerboard and time-kill assays confirmed synergy between these two antibiotics. Further synergies of oritavancin and ampicillin with rifampin or the endogenous human antimicrobial peptide cathelicidin LL-37 were demonstrated.

AB - Weekly oritavancin plus ampicillin continuous infusion combination therapy was used to successfully treat a deep spine vancomycin-resistant Enterococcus faecium infection associated with hardware. Checkerboard and time-kill assays confirmed synergy between these two antibiotics. Further synergies of oritavancin and ampicillin with rifampin or the endogenous human antimicrobial peptide cathelicidin LL-37 were demonstrated.

KW - Ampicillin

KW - Oritavancin

KW - Vancomycin-resistant Enterococcus faecium

UR - https://www.scopus.com/pages/publications/85068174461

UR - https://www.scopus.com/inward/citedby.url?scp=85068174461&partnerID=8YFLogxK

U2 - 10.1128/AAC.02622-18

DO - 10.1128/AAC.02622-18

M3 - Article

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AN - SCOPUS:85068174461

SN - 0066-4804

VL - 63

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

M1 - e02622-18

ER -

Treatment of multidrug-resistant vancomycin-resistant enterococcus faecium hardware-associated vertebral osteomyelitis with oritavancin plus ampicillin

Abstract

Keywords

ASJC Scopus subject areas

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