Treatment of multidrug-resistant vancomycin-resistant enterococcus faecium hardware-associated vertebral osteomyelitis with oritavancin plus ampicillin

Samira Dahesh, Brian Wong, Victor Nizet, George Sakoulas, Truc T. Tran, Samuel L. Aitken

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Weekly oritavancin plus ampicillin continuous infusion combination therapy was used to successfully treat a deep spine vancomycin-resistant Enterococcus faecium infection associated with hardware. Checkerboard and time-kill assays confirmed synergy between these two antibiotics. Further synergies of oritavancin and ampicillin with rifampin or the endogenous human antimicrobial peptide cathelicidin LL-37 were demonstrated.

Original languageEnglish (US)
Article numbere02622-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number7
DOIs
StatePublished - 2019

Keywords

  • Ampicillin
  • Oritavancin
  • Vancomycin-resistant Enterococcus faecium

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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