Treatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report

Yan Xia, Xiaopeng Tian, Juntao Wang, Dongjuan Qiao, Xianhao Liu, Liang Xiao, Wenli Liang, Dongcheng Ban, Junjun Chu, Jiaming Yu, Rongfu Wang, Geng Tian, Mingjun Wang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

This article presented a case of a human leukocyte antigen (HLA)-A2-positive patient with advanced cancer/testis antigen New York esophageal squamous cell carcinoma-1 (NY-ESO-1) expressing lung adenocarcinoma (LADC) who received adoptive cell therapy of T cell receptor engineered-T cells (TCR-T cells) targeting the cancer-testis antigen NY-ESO-1. The appropriate clinical and laboratory assessments were conducted to investigate the safety and efficacy of this therapy for this lung cancer patient. The patient had a clinical response to and was well-tolerated with this therapy in the clinical trial. In addition, a preliminary evaluation of the safety of NY-ESO-1 TCR-T cell therapy was performed in four patients with non-small cell lung cancer (NSCLC) enrolled in a clinical trial. It was well-tolerated and did not observe any serious adverse events post-infusion. Fever, anemia, and a decrease in white blood cell count were common adverse events, which were likely due to the TCR-T cell therapy. Two patients had clinical responses to NY-ESO-1 TCR-T cell therapy, including the 44-year-old female patient with LADC, who achieved a short-term partial response for 4 months, improved in Karnofsky performance status, and had a recovery of drug sensitivity. This suggests that TCR-T cell therapy targeting NY-ESO-1 antigen may be beneficial for HLA-A2-positive late-stage patients with NY-ESO-1-expressing NSCLC.

Original languageEnglish (US)
Pages (from-to)6998-7007
Number of pages10
JournalOncology Letters
Volume16
Issue number6
DOIs
StatePublished - Dec 1 2018

Keywords

  • Adoptive cell therapy
  • Lung adenocarcinoma
  • Non-small cell lung cancer
  • NY-ESO-1
  • TCR-engineered T cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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