Treatment of experimental stroke with opiate antagonists. Effects on neurological function, infarct size, and survival

D. S. Baskin, Y. Hosobuchi, J. C. Grevel

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The effects are reported of acute and long-term continuous administration of three opiate antagonists - naloxone, naltrexone, and diprenorphine - on neurological function, survival, and infarct size in a feline model of acute focal cerebral ischemia. All three drugs produced statistically significant improvement in motor function following acute aministration without concomitant changes in level of consciousness; saline had no effect. Naloxone and naltrexone significantly prolonged survival (p < 0.01); diprenorphine did not. Infarct size was not altered by any treatment administered. These findings confirm previous work suggesting that, with the appropriate methodology, treatment with opiate antagonists partially reverses neurological deficits. They also show that opiate antagonists prolong survival in certain conditions of acute and subacute focal cerebral ischemia without altering the area of infarcted tissue.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalJournal of Neurosurgery
Volume64
Issue number1
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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