Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas

Andrew M. Heitzer, Lisa S. Kahalley, Charles G. Minard, Claire Stafford, David R. Grosshans, M. Fatih Okcu, Kimberly P. Raghubar, Marsha Gragert, Mark McCurdy, Emily H. Warren, Jocelyn Gomez, M. Douglas Ris, Arnold C. Paulino, Murali Chintagumpala

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The relationship between age and neurocognitive functioning following proton beam radiotherapy (PRT) in low- and intermediate-grade gliomas (LIGG) has yet to be examined. Eighteen LIGG patients treated with PRT were prospectively enrolled and received annual neurocognitive evaluations of perceptual/verbal reasoning, working memory, and processing speed postradiotherapy. The median age at diagnosis was 8.2 years (range 1.0–14.7) and the median age at PRT was 9.9 years (range 4.2–17.0). Patients' neurocognitive performance did not change on any measure following PRT (p ≥.142). We did not observe significant changes in cognitive function over time among a small group of LIGG patients treated with PRT.

Original languageEnglish (US)
Article numbere29096
JournalPediatric Blood and Cancer
Volume68
Issue number8
DOIs
StatePublished - Aug 2021

Keywords

  • cognition
  • low-grade glioma
  • pediatric brain tumor
  • proton radiotherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Treatment age and neurocognitive outcomes following proton beam radiotherapy for pediatric low- and intermediate-grade gliomas'. Together they form a unique fingerprint.

Cite this